NDLI: Regulation of glucose transport by thyroid hormone in rat ovary

Content Provider	Springer Nature Link
Author	Ding, Yu Tian, Ye Guo, Meng Liu, Juan Heng, Dai Zhu, Baochang Yang, Yanzhou Zhang, Cheng
Copyright Year	2016
Abstract	Thyroid hormone (TH) plays an important role in regulating ovarian development. However, the mechanism involved remains unclear. Evidence suggests that glucose is essential for ovarian development, and its uptake is mediated by several glucose transporter proteins (Glut). We have investigated the effects of TH on Glut in rat ovary. Immature rats were treated with 6-propyl-2-thiouracil or L-thyroxine to induce hypothyroidism (hypo) or hyperthyroidism (hyper), respectively. Ovarian weights significantly decreased in both treated groups compared with the control group, although the body weights were not markedly altered. Glut1 expression significantly decreased without further changes being detected in the other Glut isforms in the hypo group and was accompanied by minimal change in mRNA content. The expression of Glut1 decreased in the hyper group. In contrast, L-thyroxine significantly increased Glut4 mRNA level and protein content but had little effect on Glut2 and Glut3 expression. Serum glucose concentrations in the hyper group were dramatically reduced compared with those in the control group. However, the serum glucose levels in the hypo group were not significantly changed. In addition, equine chorionic gonadotropin (eCG) increased ovarian weights in both the hypo and hyper groups compared with those in the rats without eCG injection. Glut2–4 protein content was significantly increased by eCG in hyper rats. Only the Glut4 mRNA content was significantly increased by eCG in the hyper group. Although the mRNA levels were not significantly changed by eCG in the hypo group, the protein level of Glut4 was markedly up-regulated. Serum glucose levels were not significantly altered by eCG in the two groups. Thus, dysfunction of the thyroid gland changes Glut expression in rat ovary and ovarian growth, both of which are also regulated by gonadotropin.
Starting Page	455
Ending Page	466
Page Count	12
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	366
Issue Number	2
e-ISSN	14320878
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-07-14
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Thyroid hormone (TH) Glucose Glut Ovary Rat Human Genetics Proteomics Molecular Medicine
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Localization of growth hormone receptors in rat and human thyroid cells

Changes in gene expression of DOR and other thyroid hormone receptors in rat liver during acute-phase response

Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturation

Cell volume regulation in immune cell apoptosis

Regulation of expression of Sertoli cell glucose transporters 1 and 3 by FSH, IL1β, and bFGF at two different time-points in pubertal development

FMRF-amide is a glucose-lowering hormone in the snail Helix aspersa

Galanin in adrenocorticotropic hormone cells is decreased by castration

Effect of growth hormone on steroid content, proliferation and apoptosis in the chicken ovary during sexual maturation

Counting in oogenesis

Regulation of glucose transport by thyroid hormone in rat ovary

Similar Documents

Localization of growth hormone receptors in rat and human thyroid cells

Changes in gene expression of DOR and other thyroid hormone receptors in rat liver during acute-phase response

Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturation

Cell volume regulation in immune cell apoptosis

Regulation of expression of Sertoli cell glucose transporters 1 and 3 by FSH, IL1β, and bFGF at two different time-points in pubertal development

FMRF-amide is a glucose-lowering hormone in the snail Helix aspersa

Galanin in adrenocorticotropic hormone cells is decreased by castration

Effect of growth hormone on steroid content, proliferation and apoptosis in the chicken ovary during sexual maturation

Counting in oogenesis

Regulation of glucose transport by thyroid hormone in rat ovary