NDLI: Presence and location of endothelin and endothelin-binding sites in human nasal mucosa under normal and metaplastic conditions

Content Provider	Springer Nature Link
Author	Gulisa, M. Barni, Tullio Fantoni, Guido Polli, Gianni Porzio, Paolo Pacini, Paolo Vannelli, Gabriella
Copyright Year	1998
Abstract	The presence and site of production of endothelin-1 (ET-1) was investigated in biopsies obtained from the nasal mucosa of 10 healthy human subjects and 10 patients affected by chronic rhinitis. The presence and localization of receptors for ET-1 was also investigated. Bioptic fragments were examined by scanning electron microscopy. ET-1 was present in the vessels and in the respiratory epithelium of normal subjects, whereas in patients affected by epithelial metaplasia induced by chronic rhinitis, it was absent in the metaplastic epithelium and present in the endothelium and vascular wall. Receptors for ET (A- and B-receptor subtypes) were localized in the vessels of the nasal mucosa, both in normal and in pathological subjects. In particular, A-receptors were identified in the vascular wall, whereas B-receptors were mainly distributed in the endothelium. We suggest that ET-1 is involved in the homeostasis of nasal blood flow (shunting the blood toward the deep cavernous plexus and inducing mucosal swelling) by an autocrine and/or paracrine mechanism. Normal epithelium seems to be important in this mechanism, since it is able to produce ET. However, when pathologic conditions induce squamous or cuboidal metaplasia, the epithelium is no longer able to play this role.
Starting Page	509
Ending Page	516
Page Count	8
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	293
Issue Number	3
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-08-26
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Distributional characteristics of lymphatic vessels in normal human nasal mucosa and sinus mucosa

Olfactory neuron-specific expression of NeuroD in mouse and human nasal mucosa

The endothelin system in human and monkey ovaries: in situ gene expression of the different components

Normal Anatomy, Histology, and Spontaneous Pathology of the Nasal Cavity of the Cynomolgus Monkey (Macaca fascicularis).

Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa

A case of nasal inverted papilloma cytology.

Cytokeratin 19 expression in human gastrointestinal mucosa during human prenatal development and in gastrointestinal tumours: relation to cell proliferation

Normal Structure, Function, and Histology of Mucosa-Associated Lymphoid Tissue

Physiological response of bovine subcommissural organ to endothelin 1 and bradykinin

Presence and location of endothelin and endothelin-binding sites in human nasal mucosa under normal and metaplastic conditions

Similar Documents

Distributional characteristics of lymphatic vessels in normal human nasal mucosa and sinus mucosa

Olfactory neuron-specific expression of NeuroD in mouse and human nasal mucosa

The endothelin system in human and monkey ovaries: in situ gene expression of the different components

Normal Anatomy, Histology, and Spontaneous Pathology of the Nasal Cavity of the Cynomolgus Monkey (Macaca fascicularis).

Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa

A case of nasal inverted papilloma cytology.

Cytokeratin 19 expression in human gastrointestinal mucosa during human prenatal development and in gastrointestinal tumours: relation to cell proliferation

Normal Structure, Function, and Histology of Mucosa-Associated Lymphoid Tissue

Physiological response of bovine subcommissural organ to endothelin 1 and bradykinin

Presence and location of endothelin and endothelin-binding sites in human nasal mucosa under normal and metaplastic conditions