NDLI: Regulation of gap junction connexins in the endometrium during early pregnancy

Content Provider	Springer Nature Link
Author	Grümmer, Ruth Winterhager, E.
Copyright Year	1998
Abstract	In mammalian species embryo implantation into uterine tissue is restricted to a limited time period, the receptive phase. For successful implantation appropriate differentiation of the receptive endometrium is under the control of ovarian steroid hormones. In addition, locally acting embryonic signals are needed to modulate the maternal environment before invasion of the trophoblast is permitted. The expression pattern of gap junction channel proteins, connexins (cx), is directly related to this process. In rodents as well as in rabbit and humans the receptive endometrium is characterized by a lack of such cell-to-cell communication channels. In the rat endometrium cx26 is suppressed in the epithelium and cx43 in the stromal compartment by maternal progesterone, a phenomenon that can be observed similarly in human endometrium. Experimental approaches revealed that both connexin genes react very sensitively to progesterone and estrogen treatment. In rat and rabbit connexin expression is induced locally in the endometrium in response to the implanting blastocyst. In both species this induction of connexins can be mimicked by a traumatic stimulus. In conclusion, suppression of connexin expression in the endometrium is a characteristic cell biological indication for receptivity in different species. The limited induction of direct cell-to-cell communication properties, probably due to locally acting blastocyst signals, seems to be a precondition for embryo implantation.
Starting Page	189
Ending Page	194
Page Count	6
File Format	PDF
ISSN	0302766X
Journal	Cell and Tissue Research
Volume Number	293
Issue Number	2
e-ISSN	14320878
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-07-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Pathology and Forensic Medicine

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