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| Content Provider | Springer Nature Link |
|---|---|
| Author | Biscetti, Federico Straface, Giuseppe Giovannini, Silvia Santoliquido, Angelo Angelini, Flavia Santoro, Luca Porreca, Carlo Filippo Pecorini, Giovanni Ghirlanda, Giovanni Flex, Andrea |
| Copyright Year | 2012 |
| Abstract | Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. The present study aimed to evaluate whether OPG gene (TNFRSF11B) polymorphisms are involved in ischemic stroke in an Italian population with diabetes. Participants in a retrospective case–control study included 364 diabetic patients (180 males, 184 females) with history of ischemic stroke and 492 diabetic subjects without history of ischemic stroke (252 males, 240 females). The T245G, T950C, and G1181C polymorphisms of the OPG gene were analyzed by polymerase chain reaction and restriction fragment length polymorphism. We found that the T245G, T950C, and G1181C gene polymorphisms of the OPG gene were significantly (34.1 vs. 9.5 %, P < 0.0001; 30.8 vs. 6.3 %, P < 0.0001 and 26.4 vs. 11.6 % P < 0.0001, respectively) and independently (adjusted OR 5.15 [3.46–7.68], OR 6.63 [4.26–10.31], and OR 3.03 [2.04–4.50], respectively) associated with history of ischemic stroke. We also found that these three polymorphisms act synergistically in patients with stroke history. The TNFRSF11B gene polymorphisms studied are associated with history of ischemic stroke and synergistic effects between these genotypes might be potential markers for cerebrovascular disorders. |
| Starting Page | 49 |
| Ending Page | 55 |
| Page Count | 7 |
| File Format | |
| ISSN | 03406717 |
| Journal | Human Genetics |
| Volume Number | 132 |
| Issue Number | 1 |
| e-ISSN | 14321203 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2012-09-11 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Human Genetics Molecular Medicine Gene Function Metabolic Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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