NDLI: Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations

Content Provider	Springer Nature Link
Author	Nakamura, Kazuhiko Chen, Chih Ken Sekine, Yoshimoto Iwata, Yasuhide Anitha, A. Loh, El Wui Takei, ri Suzuki, Atsuko Kawai, Masayoshi Takebayashi, Kiyokazu Suzuki, Katsuaki Minabe, Yoshio Tsuchiya, Kenji Yamada, Kazuo Iyo, Masaomi Ozaki, rio Inada, Toshiya Iwata, Nakao Hara, Mutsuo Komiyama, Tokutaro Yamada, Mitsuhiko Sora, Ichiro Ujike, Hiroshi Ball, David M. Yoshikawa, Takeo Lin, Shih Ku Mori, rio
Copyright Year	2006
Abstract	SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes: a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.
Starting Page	243
Ending Page	252
Page Count	10
File Format	PDF
ISSN	03406717
Journal	Human Genetics
Volume Number	120
Issue Number	2
e-ISSN	14321203
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-06-29
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Metabolic Diseases Internal Medicine Molecular Medicine Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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