NDLI: Linkage disequilibrium between microsatellite markers in the Swedish Sami relative to a worldwide selection of populations

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Linkage disequilibrium between microsatellite markers in the Swedish Sami relative to a worldwide selection of populations

Content Provider	Springer Nature Link
Author	Johansson, Åsa Vavruch Nilsson, Veronika Edin Liljegren, Anette Sjölander, Per Gyllensten, Ulf
Copyright Year	2004
Abstract	The pattern of linkage disequilibrium (LD) is affected by a number of factors, including population demography. High LD is seen in populations with a relatively limited and constant size, presumably because of genetic drift. We have examined the extent of LD among over 300 genome-wide pattern microsatellite loci in 29 populations from around the world. The pattern of LD varied between populations, with a larger extent of LD in populations with limited size relative to larger populations. In addition, the LD between 88 less well-spaced microsatellite markers from 10 different genomic regions was examined in the Sami compared with the general Swedish population. For these markers, increased LD extending up to 5 Mb was detected in the Sami. The amount of LD also differed between the chromosomal regions. The amount of LD in the Sami makes this population suitable for the mapping of complex genetic traits.
Starting Page	105
Ending Page	113
Page Count	9
File Format	PDF
ISSN	03406717
Journal	Human Genetics
Volume Number	116
Issue Number	1-2
e-ISSN	14321203
Language	English
Publisher	Springer-Verlag
Publisher Date	2004-11-11
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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