NDLI: Phenotypic subregions within the split-hand/foot malformation 1 locus

Content Provider	Springer Nature Link
Author	Rasmussen, Malene B. Kreiborg, Sven Jensen, Per Bak, Mads Mang, Yuan Lodahl, Marianne Budtz Jørgensen, Esben Tommerup, Niels Tranebjærg, Lisbeth Rendtorff, Nanna D.
Copyright Year	2016
Abstract	Split-hand/foot malformation 1 (SHFM1) is caused by chromosomal aberrations involving the region 7q21.3, DLX5 mutation, and dysregulation of DLX5/DLX6 expression by long-range position effects. SHFM1 can be isolated or syndromic with incomplete penetrance and a highly variable clinical expression, possibly influenced by sex and imprinting. We report on a new family with five affected individuals with syndromic SHFM1 that includes split-hand/foot malformations, hearing loss, and craniofacial anomalies, and an inv(7)(q21.3q35) present both in the proband and her affected son. The proximal inversion breakpoint, identified by next generation mate-pair sequencing, truncates the SHFM1 locus within the regulatory region of DLX5/6 expression. Through genotype-phenotype correlations of 100 patients with molecularly characterized chromosomal aberrations from 32 SHFM1 families, our findings suggest three phenotypic subregions within the SHFM1 locus associated with (1) isolated SHFM, (2) SHFM and hearing loss, and (3) SHFM, hearing loss, and craniofacial anomalies, respectively (ranked for increasing proximity to DLX5/6), and encompassing previously reported tissue-specific enhancers for DLX5/6. This uniquely well-characterized cohort of SHFM1 patients allowed us to systematically analyze the recently suggested hypothesis of skewed transmission and to confirm a higher penetrance in males vs. females in a subgroup of patients with isolated SHFM.
Starting Page	345
Ending Page	357
Page Count	13
File Format	PDF
ISSN	03406717
Journal	Human Genetics
Volume Number	135
Issue Number	3
e-ISSN	14321203
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-02-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Molecular Medicine Gene Function Metabolic Diseases
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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