NDLI: IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy

Please wait, while we are loading the content...

Independent methods for evolutionary genetic dating provide insights into Y-chromosomal STR mutation rates confirming data from direct father–son transmissions

Genetic prion disease: the EUROCJD experience

A type II collagen mutation also results in oto-spondylo-megaepiphyseal dysplasia

Familial aggregation in lone atrial fibrillation

Analysis of missense variants in the PKHD1-gene in patients with autosomal recessive polycystic kidney disease (ARPKD)

Direct duplication 12p11.21–p13.31 mediated by segmental duplications: a new recurrent rearrangement?

The position of premature termination codons in the hepatocyte nuclear factor −1 beta gene determines susceptibility to nonsense-mediated decay

Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis

Major histocompatibility complex and alveolar epithelial apoptosis in idiopathic pulmonary fibrosis

Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns

Mortality and cancer incidence in women with extra X chromosomes: a cohort study in Britain

A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification

Molecular analysis of a constitutional complex genome rearrangement with 11 breakpoints involving chromosomes 3, 11, 12, and 21 and a ∼0.5-Mb submicroscopic deletion in a patient with mild mental retardation

Genetic variability in a genomic region with long-range linkage disequilibrium reveals traces of a bottleneck in the history of the European population

Interaction between inflammation-related gene polymorphisms and cigarette smoking on the risk of myocardial infarction in the Physician’s Health Study

IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy

DNA Methylation and Replication: Implications for the “Deletion Hotspot” Region of FMR1

A genetic and cultural odyssey. The life and work of L. Luca Cavalli-Sforza (2005). By Linda Stone, Columbia University Press, 248

A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region

Human Genetics : Volume 118, Issue 1, November 2005

Human Genetics : Volume 117

Human Genetics : Volume 116

Human Genetics : Volume 115

Human Genetics : Volume 114

Human Genetics : Volume 113

Human Genetics : Volume 112

Human Genetics : Volume 111

Human Genetics : Volume 110

Human Genetics : Volume 109

Human Genetics : Volume 108

Human Genetics : Volume 107

Human Genetics : Volume 106

Human Genetics : Volume 105

Human Genetics : Volume 104

Human Genetics : Volume 103

Human Genetics : Volume 102

Human Genetics : Volume 101

Human Genetics : Volume 100

Human Genetics : Volume 99

IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy

Content Provider	Springer Nature Link
Author	Malhotra, Dheeraj Darvishi, Katayoon Sood, Soni Sharma, Swarkar Grover, Chander Relhan, Vineet Reddy, B. S. N. Bamezai, R. N. K.
Copyright Year	2005
Abstract	The minor haplotype −3575A/-2849G/-2763C in IL-10 promoter has been defined as a marker of disease resistance to leprosy and its severity in Brazilian population. Our investigation of six single-nucleotide polymorphisms (SNPs) in IL-10 promoter in 282 Indian leprosy patients and 266 healthy controls by direct PCR sequencing, however, showed that the extended haplotype: −3575T/-2849G/-2763C/-1082A/-819C/-592C was associated with resistance to leprosy per se and to the development of severe form of leprosy, using either a binomial (controls vs cases, P=0.01, OR=0.58, CI=0.37–0.89) or ordinal (controls vs paucibacillary vs multibacillary, P=0.004) model. Whereas, IL-10 haplotype −3575T/-2849G/-2763C/-1082A/-819T/-592A was associated with the risk of development of severe form of leprosy (P=0.0002) in contrast to the minor risk haplotype −3575T/-2849A/-2763C in the Brazilian population. The role of IL-10 promoter SNPs in Brazilian and Indian population strongly suggests the involvement of IL-10 locus in the outcome of leprosy.
Starting Page	295
Ending Page	300
Page Count	6
File Format	PDF
ISSN	03406717
Journal	Human Genetics
Volume Number	118
Issue Number	2
e-ISSN	14321203
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-09-15
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness

The −1030/−862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia

Single nucleotide polymorphisms in candidate genes are significantly associated with resistance to Haemonchus contortus infection in goats

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production

Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.

Interleukin-8 and -10 gene polymorphisms in irritable bowel syndrome

IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan.

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production

IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy

Similar Documents

Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness

The −1030/−862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia

Single nucleotide polymorphisms in candidate genes are significantly associated with resistance to Haemonchus contortus infection in goats

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production

Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.

Interleukin-8 and -10 gene polymorphisms in irritable bowel syndrome

IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan.

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production

IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy