NDLI: Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders

Content Provider	Springer Nature Link
Author	Ligthart, Lannie Hottenga, Jouke Jan Lewis, Cathryn M. Farmer, Anne E. Craig, Ian W. Breen, Gerome Willemsen, Gonneke Vink, Jacqueline M. Middeldorp, Christel M. Byrne, Enda M. Heath, Andrew C. Madden, Pamela A. F. Pergadia, Michele L. Montgomery, Grant W. Martin, Nicholas G. Penninx, Brenda W. J. H. McGuffin, Peter Boomsma, Dorret I. Nyholt, Dale R.
Copyright Year	2013
Abstract	Migraine and major depressive disorder (MDD) are comorbid, moderately heritable and to some extent influenced by the same genes. In a previous paper, we suggested the possibility of causality (one trait causing the other) underlying this comorbidity. We present a new application of polygenic (genetic risk) score analysis to investigate the mechanisms underlying the genetic overlap of migraine and MDD. Genetic risk scores were constructed based on data from two discovery samples in which genome-wide association analyses (GWA) were performed for migraine and MDD, respectively. The Australian Twin Migraine GWA study (N = 6,350) included 2,825 migraine cases and 3,525 controls, 805 of whom met the diagnostic criteria for MDD. The RADIANT GWA study (N = 3,230) included 1,636 MDD cases and 1,594 controls. Genetic risk scores for migraine and for MDD were used to predict pure and comorbid forms of migraine and MDD in an independent Dutch target sample (NTR–NESDA, N = 2,966), which included 1,476 MDD cases and 1,058 migraine cases (723 of these individuals had both disorders concurrently). The observed patterns of prediction suggest that the ‘pure’ forms of migraine and MDD are genetically distinct disorders. The subgroup of individuals with comorbid MDD and migraine were genetically most similar to MDD patients. These results indicate that in at least a subset of migraine patients with MDD, migraine may be a symptom or consequence of MDD.
Starting Page	173
Ending Page	186
Page Count	14
File Format	PDF
ISSN	03406717
Journal	Human Genetics
Volume Number	133
Issue Number	2
e-ISSN	14321203
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-10-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Molecular Medicine Gene Function Metabolic Diseases
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders

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