NDLI: Lingo2 variants associated with essential tremor and Parkinson’s disease

Content Provider	Springer Nature Link
Author	Wu, Yi Wen Prakash, K. M. Rong, Tian Yi Li, Hui Hua Xiao, Qin Tan, Louis C. Au, Wing Lok Ding, Jian qing Chen, Sheng di Tan, Eng King
Copyright Year	2011
Abstract	LINGO2, a member of LRR gene family, has been linked with both Essential tremor (ET) and Parkinson’s disease (PD). However, there is a lack of conclusive evidence regarding the etiologic role of LINGO2 genetic variants. We investigated the association of LINGO2 variants with ET and PD in two independent Asian countries. A total of 1,262 subjects comprising 499 controls, 436 PD patients, and 327 ET patients were included. Eight LINGO2 variants, including four single-nucleotide polymorphisms (SNPs) and four coding variants, were initially analyzed in one Asian population. SNPs that showed positive association were then replicated in the second independent Asian population, and a pooled analysis was carried out. Out of the eight variants, two SNPs (rs7033345 and rs10812774) revealed significant or strong positive trend in the first Asian population, and these were analyzed in the second Asian population. In the pooled analysis, the CC genotype at rs7033345 had a higher risk of developing PD (OR = 1.67, 95% CI = 1.18, 2.35, p = 0.003) and ET (OR = 1.50, 95% CI = 1.02, 2.20, p = 0.04) under a recessive model. The C allele at rs10812774 increased the risk of ET (OR = 1.56 95% CI = 1.10, 2.22, p = 0.01) via a recessive model. The effect size and direction of trend were in the same direction in each of the two populations. Our study demonstrated for the first time that rs7033345 is associated with PD and ET and rs10812774 with ET among Asians, suggesting that LINGO2 might act as a susceptibility gene for both conditions.
Starting Page	611
Ending Page	615
Page Count	5
File Format	PDF
ISSN	03406717
Journal	Human Genetics
Volume Number	129
Issue Number	6
e-ISSN	14321203
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-02-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Metabolic Diseases Molecular Medicine Human Genetics Gene Function
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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