NDLI: Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks

Content Provider	Springer Nature Link
Author	Riccio, Evelyn K. P. Júnior, Ivan Neves Riccio, Lilian R. Pratt das Graças Alecrim, Maria Corte Real, Suzana Morgado, Mariza Daniel Ribeiro, Cláudio T. de Fátima Ferreira da Cruz, Maria
Copyright Year	2003
Abstract	The occurrence and intensity of lymphocyte apoptosis in blood samples from 79 outclinic patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria and 30 healthy individuals were investigated. No difference in apoptosis percentages was detected between healthy individuals and malaria patients when ex vivo lymphocytes were analyzed. However, significantly increased apoptosis levels were observed in lymphocytes from both P. falciparum- and P. vivax-infected patients when the cells were cultured for 24 h. CD4+ and CD8+ T cells were affected to a comparable extent in P.falciparum- and P.vivax-infected patients. However, when we compared apoptosis values in infected and non-infected individuals it appeared that CD4+ T cells were more susceptible than CD8+ T cells. A significant increase in the sIL-2R plasma levels was observed in malaria patients when compared with healthy individuals and a positive correlation was observed between sIL-2R levels and apoptosis rates in infected patients presenting increased rates of apoptosis. An increased expression of Fas antigen was recorded after stimulation with P. falciparum antigen or anti-CD3 monoclonal antibody. These data show that a consistent proportion of the lymphocyte population dies by apoptosis during a malaria infection and that a period of time is necessary before in vivo activated cells can express the apoptotic process in vitro.
Starting Page	9
Ending Page	18
Page Count	10
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	90
Issue Number	1
e-ISSN	14321955
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-01-28
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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