NDLI: Pharmacokinetics and anthelmintic efficacy of topical eprinomectin in goats prevented from grooming

Content Provider	Springer Nature Link
Author	Rehbein, Steffen Kellermann, Michael Wehner, Teresa A.
Copyright Year	2014
Abstract	Pharmacokinetics and anthelmintic activity of topical eprinomectin in goats prevented from physical contact to others and self-grooming were studied. Sixteen approximately 7 months old male castrated German White Noble goats harbouring induced infections of gastrointestinal nematode parasites were included in the study. They were blocked based on pre-treatment body weight (range 22.4 to 36.4 kg) and then randomly allocated to the untreated control group or the group treated with topical 0.5 % w/v eprinomectin (EPRINEX® Pour-on, Merial) at 1 mg/kg body weight. Plasma samples were collected prior to and at intervals up to 14 days following treatment and analyzed to determine the concentrations of eprinomectin (B1a component). Parasites were recovered, identified, and counted following necropsy 14 days after treatment. Goats treated with topical eprinomectin had significantly fewer (≥99 % reduction, p < 0.01) adult Cooperia curticei, Haemonchus contortus, Nematodirus battus, Oesophagostomum venulosum, Ostertagia circumcincta, and Trichostrongylus colubriformis than the untreated controls. Basic pharmacokinetic parameters for eprinomectin B1a were AUCinfinity, 37.1 ± 15.2 day ng/mL; T½, 5.11 ± 2.83 days; and Cmax, 5.93 ± 1.87 ng/mL; individual maximal concentrations were observed 1 or 2 days after treatment. Results of this study indicate that oral ingestion is not required to achieve adequate exposure for excellent anthelmintic efficacy following topical administration of eprinomectin at 1 mg/kg body weight to goats.
Starting Page	4039
Ending Page	4044
Page Count	6
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	113
Issue Number	11
e-ISSN	14321955
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-08-09
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Eprinomectin Topical formulation Pharmacokinetics Efficacy Nematodes Goats Medical Microbiology Microbiology Immunology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Anthelmintic action of eprinomectin in lactating Anglo-Nubian goats in Brazil

Reevaluation of efficacy against nematode parasites and pharmacokinetics of topical eprinomectin in cattle

Prevalence of anthelmintic resistance in gastrointestinal nematodes of sheep and goats in Norway

Prevalence of multiple anthelmintic resistant gastrointestinal nematodes in dairy goats in a desolated tract (Pakistan)

Efficacy of eprinomectin against Toxacara canis in dogs

Comparative Efficacy of Trichlorphon and Trichlorphon/Ivermectin Combination Treatment against Anthelmintic-Resistant Cattle Nematodes in Argentina

The Efficacy of Trichlorphon and Naphthalophos against Multiple Anthelmintic-Resistant Nematodes of Naturally Infected Sheep in Argentina

Anthelmintic effect of heather in goats experimentally infected with Trichostrongylus colubriformis

Persistent efficacy of topical eprinomectin against nematode parasites in cattle

Pharmacokinetics and anthelmintic efficacy of topical eprinomectin in goats prevented from grooming

Similar Documents

Anthelmintic action of eprinomectin in lactating Anglo-Nubian goats in Brazil

Reevaluation of efficacy against nematode parasites and pharmacokinetics of topical eprinomectin in cattle

Prevalence of anthelmintic resistance in gastrointestinal nematodes of sheep and goats in Norway

Prevalence of multiple anthelmintic resistant gastrointestinal nematodes in dairy goats in a desolated tract (Pakistan)

Efficacy of eprinomectin against Toxacara canis in dogs

Comparative Efficacy of Trichlorphon and Trichlorphon/Ivermectin Combination Treatment against Anthelmintic-Resistant Cattle Nematodes in Argentina

The Efficacy of Trichlorphon and Naphthalophos against Multiple Anthelmintic-Resistant Nematodes of Naturally Infected Sheep in Argentina

Anthelmintic effect of heather in goats experimentally infected with Trichostrongylus colubriformis

Persistent efficacy of topical eprinomectin against nematode parasites in cattle

Pharmacokinetics and anthelmintic efficacy of topical eprinomectin in goats prevented from grooming