NDLI: European multicenter field trial on the efficacy and safety of a topical formulation of imidacloprid and permethrin (AdvantixTM) in dogs naturally infested with ticks and/or fleas

Content Provider	Springer Nature Link
Author	Hellmann, K. Kppe, T. Krieger, K. Stanneck, D.
Copyright Year	2003
Abstract	In a field trial 363 dogs naturally infested with ticks (n ≧ 1) and/or fleas (n ≧ 5) were enrolled at 23 centres in Germany, France and Italy. A total of 229 dogs were treated once with the test product, a topical formulation of imidacloprid 10% and permethrin 50%. 134 dogs were treated once with a registered control product, a topical fipronil 10% formulation, according to the label instructions. All dogs and cats living in the same household were treated with the control product. Cats living with the imidacloprid-permethrin treated dogs were treated with a mono imidacloprid formulation. Efficacy and safety of the products were assessed 2 days and 1,2,3 and 4 weeks after treatment by individual parasite counts and clinical examination. Continuous infestation pressure during the trial period was demonstrated by monitoring other dogs presented to the clinics. Efficacy calculations were based on geometric means of the individual parasite counts compared to pre-treatment infestation. The acute efficacy (day 2) of the imidacloprid permethrin combination vs. the control product was 91.1% vs. 89.7% against Ixodes. ricinus, 85.4% vs. 80.9% against Rhipicephalus spp. and 98.3% vs. 97.0% against Ctenocephalides spp. Residual efficacy (day 28) of the two products was 95.2% vs. 69.5% against I. ricinus, 98.5% vs. 89.4% against R.. spp. and 92.5% vs. 93.5% against C. spp. Results of the trial proved the safety of both products in treated dogs and in dogs and cats, living in the same household.
Starting Page	S125
Ending Page	S126
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	90
Issue Number	3
e-ISSN	14321955
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-08-19
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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