NDLI: Factors affecting the anthelmintic efficacy of papaya latex in vivo: host sex and intensity of infection

Content Provider	Springer Nature Link
Author	Luoga, Wenceslaus Mansur, Fadlul Lowe, Ann Duce, Ian R. Buttle, David. J. Behnke, Jerzy M.
Copyright Year	2015
Abstract	The development of plant-derived cysteine proteinases, such as those in papaya latex, as novel anthelmintics requires that the variables affecting efficacy be fully evaluated. Here, we conducted two experiments, the first to test for any effect of host sex and the second to determine whether the intensity of the worm burden carried by mice would influence efficacy. In both experiments, we used the standard C3H mouse reference strain in which papaya latex supernatant (PLS) consistently shows >80 % reduction in Heligmosomoides bakeri worm burdens, but to broaden the perspective, we also included for comparison mice of other strains that are known to respond more poorly to treatment with papaya latex. Our results confirmed that there is a strong genetic influence affecting efficacy of PLS in removing adult worm burdens. However, there was no effect of host sex on efficacy (C3H and NIH) and no effect of infection intensity (C3H and BALB/c). These results offer optimism that plant-derived cysteine proteinases (CPs), such as these from papaya latex, can function as effective anthelmintics, with neither host sex nor infection intensity presenting further hurdles to impede their development for future medicinal and veterinary usage.
Starting Page	2535
Ending Page	2541
Page Count	7
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	114
Issue Number	7
e-ISSN	14321955
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-04-10
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Papaya latex Cysteine proteinases Heligmosomoides (polygyrus) bakeri Mouse C3H NIH BALB/c Host sex Intensity of worm burden Medical Microbiology Microbiology Immunology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode,Heligmosomoides polygyrus,in vitro

The effects of plant cysteine proteinases on the nematode cuticle

The production of excretory-secretory molecules from Heligmosomoides polygyrus bakeri fourth stage larvae varies between mixed and single sex cultures

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