NDLI: Bioassay-guided isolation and identification of active compounds from Fructus Arctii against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus)

Content Provider	Springer Nature Link
Author	Wang, Gao xue Han, Jing Feng, Ting ting Li, Fu yuan Zhu, Bin
Copyright Year	2009
Abstract	Dactylogyrus intermedius is a significant monogenean parasite on the gills of cyprinid fishes and can cause serious problem in fish aquaculture. In the present study, bioassay-guided fractionation was employed to identify the active compounds from Fructus Arctii against D. intermedius. Five solvents (petroleum ether, chloroform, ethyl acetate, ethanol, and water) were applied for the extraction of Fructus Arctii. Among them, only the chloroform extract exhibited promising anthelmintic efficacy and therefore, subjected to the further isolation and purification using various chromatographic techniques. Two compounds showing potent activity were obtained and identified by spectral data (infrared, nuclear magnetic resonance, and mass spectrometry) as: arctigenin (1) and arctiin (2). They were found to be significantly effective against D. intermedius with median effective concentration (EC50) values of 0.62 and 3.55 mg L−1, respectively. Arctigenin exhibited higher activity as compared with the positive control mebendazole with an EC50 value of 1.25 mg L−1. The 48-h acute toxicity tests (LC50) of arctigenin and arctiin were found to be 8.47 and 14.14 mg L−1 for goldfish, respectively. These results provided evidence that the studied plant extract, as well as the isolated compounds, might be potential sources of new antiparasitic drug for the control of Dactylogyrus.
Starting Page	247
Ending Page	255
Page Count	9
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	106
Issue Number	1
e-ISSN	14321955
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-10-27
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Microbiology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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