NDLI: FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil

Content Provider	Springer Nature Link
Author	Albuquerque, Sérgio Roberto Lopes Oliveira Cavalcante, Francimary Sangui, Edalton Cesar Tezza, Lucianna Chacon, Fernanda Castilho, Lilian Santos, Maria Cristina
Copyright Year	2010
Abstract	Although the importance of glycoprotein Duffy in the human red cells invasion process by Plasmodium vivax merozoites has been demonstrated, little is known about the associations of FY polymorphisms with malaria vivax parasitic density. In this study, we investigated the associations of the SNPs 125 G>A, 265 C>T, and 298 G>A on FY gene and the SNP –33T>C on GATA box with the vivax malaria parasitic density in inhabitants of Amazon State, Brazil. Verifications of P. vivax, as well as the definition of parasitism, were determined by standard screening tests in 497 patients. FY phenotyping was performed in all samples by hemagglutination using gel cards. Molecular analysis for FY/GATA polymorphisms were performed by polymerase chain reaction–restriction fragment length polymorphism. Our data showed that in this population, FYA/FYB-33 and FYB/FYB-33 genotypes may be a selective advantage, reducing the frequency of P. vivax infection in the studied area. FYA/FYB and FYA/FYA genotypes showed to be associated with the rise of the frequency of P. vivax infection, and FYB/FYX and FYA/FYX showed to be associated with the low levels of parasitism. These results suggest that natural adaptations, in malaria-endemic regions, could be leading to the arising of partial defense mechanisms against P. vivax, which is different from the previously described in African descents, as well as adaptations that could be increasing the susceptibility of human to this kind of malaria.
Starting Page	1049
Ending Page	1053
Page Count	5
File Format	PDF
ISSN	09320113
Journal	Parasitology Research
Volume Number	106
Issue Number	5
e-ISSN	14321955
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-02-17
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Microbiology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Veterinary Parasitology Insect Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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