NDLI: Tumor necrosis factor-α expression induced by anti-YopB antibodies coincides with protection against Yersinia enterocolitica infection in mice

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Tumor necrosis factor-α expression induced by anti-YopB antibodies coincides with protection against Yersinia enterocolitica infection in mice

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Tumor necrosis factor-α expression induced by anti-YopB antibodies coincides with protection against Yersinia enterocolitica infection in mice

Content Provider	Springer Nature Link
Author	Burdack, Susanne Schmidt, Annette Knieschies, Elsbeth Röllinghoff, Martin Beuscher, H. U.
Copyright Year	1997
Abstract	Previous studies have suggested that virulence of pathogenic Yersiniae is associated with a suppression of the local cytokine response. In this context, the plasmid-encoded 41-kDa Yersinia outer protein B (YopB) has been implicated with the lack of tumor necrosis factor-α (TNF-α) expression in Peyer's patches (PP), following oral infection of mice with the enteropathogenic Yersinia enterocolitica. The present study was performed to further evaluate the relationships between YopB-induced suppression of TNF-α and bacterial survival in host tissue. Results are presented to show the ability of purified YopB to suppress the release of TNF-α by macrophages, the effect of which was neutralized by monospecific anti-YopB antiserum. In mice orally infected with Y. enterocolitica, anti-YopB treatment on days 3 and 5 postinfection, significantly decreased the recovery of live bacteria from PP. This observation correlated with a strong increase in TNF-α expression, as determined by reverse transcription-polymerase chain reaction and measuring the levels of TNF activity in homogenates of PP. Moreover, treatment of mice with a combination of anti-YopB and anti-TNF-α antiserum, completely abrogated the beneficial effect of the anti-YopB antiserum. In controls, expression of other proinflammatory cytokines such as interleukin-1 remained unaffected by either treatment. Therefore, the results indicate that endogenous TNF-α is required for eradication of Y. enterocolitica from host tissue, and further imply that YopB significantly contributes to suppression of the local TNF-α response in PP.
Starting Page	223
Ending Page	229
Page Count	7
File Format	PDF
ISSN	03008584
Journal	Medical Microbiology and Immunology
Volume Number	185
Issue Number	4
e-ISSN	14321831
Language	English
Publisher	Springer-Verlag
Publisher Date	1997-04-09
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Microbiology (medical)

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