NDLI: Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice

Content Provider	Springer Nature Link
Author	Aerts, Jeroen Nys, Julie Moons, Lieve Hu, Tjing Tjing Arckens, Lutgarde
Copyright Year	2014
Abstract	Matrix metalloproteinases (MMPs) are Zn2+-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in synaptic plasticity, hippocampus-dependent learning and neuronal development and migration in the cerebellum. However, the function(s) of this enzyme in the neocortex is understudied. Therefore, we explored the phenotypical characteristics of the neuronal architecture and the capacity for experience-dependent cortical plasticity in the visual cortex of adult MMP-3-deficient (MMP-3−/−) mice. Golgi–Cox stainings revealed a significant reduction in apical dendritic length and an increased number of apical obliques for layer V pyramidal neurons in the visual cortex of adult MMP-3−/− mice compared to wild-type (WT) animals. In addition, a significant upregulation of both phosphorylated and non-phosphorylated neurofilament protein (NF)-high, phosphorylated NF-medium, NF-low and α-internexin was detected in the visual cortex of MMP-3−/− mice. To assess the effect of MMP-3 deficiency on cortical plasticity, we monocularly enucleated adult MMP-3−/− mice and analyzed the reactivation of the contralateral visual cortex 7 weeks post-enucleation. In contrast to previous results in C57Bl/6J adult mice, activity remained confined to the binocular zone and did not expand into the monocular regions indicative for an aberrant open-eye potentiation. Permanent hypoactivity in the monocular cortex lateral and medial to V1 also indicated a lack of cross-modal plasticity. These observations demonstrate that genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice.
Starting Page	2675
Ending Page	2689
Page Count	15
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	220
Issue Number	5
e-ISSN	18632661
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-06-25
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Matrix metalloproteinase Golgi–Cox Apical dendrite Neurofilament Monocular enucleation Multimodal Neurosciences Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice

The disorganized visual cortex in reelin-deficient mice is functional and allows for enhanced plasticity

Evidence for cross-modal plasticity in adult mouse visual cortex following monocular enucleation.

The cross-modal aspect of mouse visual cortex plasticity induced by monocular enucleation is age dependent.

Altered glutamate/GABA equilibrium in aged mice cortex influences cortical plasticity

Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

Evidence for cross-modal plasticity in adult mouse visual cortex following monocular enucleation.

Neuronal morphology in the African elephant (Loxodonta africana) neocortex

The neocortex of cetartiodactyls. II. Neuronal morphology of the visual and motor cortices in the giraffe (Giraffa camelopardalis)

Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice

Similar Documents

Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice

The disorganized visual cortex in reelin-deficient mice is functional and allows for enhanced plasticity

Evidence for cross-modal plasticity in adult mouse visual cortex following monocular enucleation.

The cross-modal aspect of mouse visual cortex plasticity induced by monocular enucleation is age dependent.

Altered glutamate/GABA equilibrium in aged mice cortex influences cortical plasticity

Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

Evidence for cross-modal plasticity in adult mouse visual cortex following monocular enucleation.

Neuronal morphology in the African elephant (Loxodonta africana) neocortex

The neocortex of cetartiodactyls. II. Neuronal morphology of the visual and motor cortices in the giraffe (Giraffa camelopardalis)

Altered neuronal architecture and plasticity in the visual cortex of adult MMP-3-deficient mice