NDLI: The effect of vestibular nerve section on the expression of the hyaluronan in the frog, Rana esculenta

Content Provider	Springer Nature Link
Author	Halasi, Gábor Wolf, Ervin Bácskai, Tímea Székely, György Módis, László Szigeti, Zsuzsa M. Mészár, Zoltán Felszeghy, Szabolcs Matesz, Clara
Copyright Year	2007
Abstract	Following postganglionic lesion of the eighth cranial nerve, the changes in the expression of hyaluronan (HA), one of the extracellular matrix macromolecules, were examined in the medial (MVN) and lateral (LVN) vestibular nuclei and in the entry or transitional zone (TZ) of the nerve in the frog. HA was detected in different survival times by using a specific biotinylated hyaluronan-binding probe. HA expression was defined by the area-integrated optical density (AIOD), calculated from pixel intensities of digitally captured images. During the first postoperative days the perineuronal net (PN), a HA-rich area around the neurons, was not distinguishable from the surrounding neuropil in the MVN and LVN, characterized by a bilateral drop of AIOD specifically on the operated side. From postoperative day 14 onwards AIOD increased whilst the PN reorganized. In contrast, the AIOD wobbled up and down bilaterally without any trend in the TZ. Statistical analysis indicated that AIOD changes in the structures studied ran parallel bilaterally presumably because of the operation. Our results demonstrated for the first time that (1) the lesion of the eighth cranial nerve is accompanied by the modification of AIOD reflected HA expression in the MVN, LVN and TZ, (2) different tendencies exist in the time course of AIOD in the structures studied and (3) these tendencies are similar on the intact and operated sides. Our findings may suggest an area dependent molecular mechanism of HA in the restoration of vestibular function.
Starting Page	321
Ending Page	334
Page Count	14
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	212
Issue Number	3
e-ISSN	18632661
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-10-02
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Extracellular matrix Vestibular system Neural regeneration Brainstem Image analysis Neurology Cell Biology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

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