NDLI: Expression of insulin-like growth factor family in the rat olfactory epithelium

Content Provider	Springer Nature Link
Author	Suzuki, Yuko Takeda, Masako
Copyright Year	2002
Abstract	The goal of this study was to determine the cellular sites of insulin-like growth factor (IGF) family expression in the rat olfactory epithelium. By RT-PCR analysis, mRNAs of IGF-I, II, IGF-I receptor (IGF-IR), and IGF binding proteins (IGFBPs) 2, 3, 4, 5, and 6 were found to be expressed in the olfactory mucosa. Immunoreactivity for IGF-IR was restricted to a subset of olfactory receptor cells whose cell bodies were situated in the basal region of the olfactory epithelium. Intense IGF-I immunoreactivity was detected in the supporting cells, whereas IGF-II immunoreactivity was observed in the lamina propria, but not in the epithelium. Immunoreactivities for IGFBP-2, IGFBP-3, and IGFBP-6 were detected in olfactory receptor cells. In addition, axon bundles in the lamina propria displayed an intense reaction for IGFBP-6. IGFBP-4 immunoreactivity was restricted to the apex of the olfactory epithelium. Intense IGFBP-5 immunoreactivity was observed in Bowman's glands. These results suggest that IGF-I is secreted from supporting cells and affects its receptor- expressing olfactory cells. IGFBPs may modulate IGF-I activity via their production by Bowman's glands, olfactory cells, and supporting cells themselves.
Starting Page	401
Ending Page	405
Page Count	5
File Format	PDF
ISSN	03402061
Journal	Anatomy and Embryology
Volume Number	205
Issue Number	5
e-ISSN	14320568
Language	English
Publisher	Springer-Verlag
Publisher Date	2002-09-04
Publisher Place	Berlin/Heidelberg
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Anatomy Cell Biology Developmental Biology Embryology

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