NDLI: Where language meets meaningful action: a combined behavior and lesion analysis of aphasia and apraxia

Content Provider	Springer Nature Link
Author	Weiss, Peter H. Ubben, Simon D. Kaesberg, Stephanie Kalbe, Elke Kessler, Josef Liebig, Thomas Fink, Gereon R.
Copyright Year	2014
Abstract	It is debated how language and praxis are co-represented in the left hemisphere (LH). As voxel-based lesion-symptom mapping in LH stroke patients with aphasia and/or apraxia may contribute to this debate, we here investigated the relationship between language and praxis deficits at the behavioral and lesion levels in 50 sub-acute stroke patients. We hypothesized that language and (meaningful) action are linked via semantic processing in Broca’s region. Behaviorally, half of the patients suffered from co-morbid aphasia and apraxia. While 24 % (n = 12) of all patients exhibited aphasia without apraxia, apraxia without aphasia was rare (n = 2, 4 %). Left inferior frontal, insular, inferior parietal, and superior temporal lesions were specifically associated with deficits in naming, reading, writing, or auditory comprehension. In contrast, lesions affecting the left inferior frontal gyrus, premotor cortex, and the central region as well as the inferior parietal lobe were associated with apraxic deficits (i.e., pantomime, imitation of meaningful and meaningless gestures). Thus, contrary to the predictions of the embodied cognition theory, lesions to sensorimotor and premotor areas were associated with the severity of praxis but not language deficits. Lesions of Brodmann area (BA) 44 led to combined apraxic and aphasic deficits. Data suggest that BA 44 acts as an interface between language and (meaningful) action thereby supporting parcellation schemes (based on connectivity and receptor mapping) which revealed a BA 44 sub-area involved in semantic processing.
Starting Page	563
Ending Page	576
Page Count	14
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	221
Issue Number	1
e-ISSN	18632661
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-10-29
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Broca’s region Brodmann areas Neuroanatomy Lesion mapping Stroke Neuropsychological assessment Neurosciences Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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P366: Where language meets action: a combined behaviour and lesion analysis of aphasia and apraxia due to left-hemisphere stroke

Mapping spoken language and cognitive deficits in post-stroke aphasia.

Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia.

Functional anomaly mapping reveals local and distant dysfunction caused by brain lesions

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A precise language network revealed by the independent component-based lesion mapping in post-stroke aphasia

Functional neuroanatomy of the insular lobe

Left cytoarchitectonic area 44 supports selection in the mental lexicon during language production

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Where language meets meaningful action: a combined behavior and lesion analysis of aphasia and apraxia

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P366: Where language meets action: a combined behaviour and lesion analysis of aphasia and apraxia due to left-hemisphere stroke

Mapping spoken language and cognitive deficits in post-stroke aphasia.

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Functional anomaly mapping reveals local and distant dysfunction caused by brain lesions

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Functional neuroanatomy of the insular lobe

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Where language meets meaningful action: a combined behavior and lesion analysis of aphasia and apraxia