NDLI: Stimulus-specific and differential distribution of activated extracellular signal-regulated kinase in the nucleus accumbens core and shell during Pavlovian-instrumental transfer

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Stimulus-specific and differential distribution of activated extracellular signal-regulated kinase in the nucleus accumbens core and shell during Pavlovian-instrumental transfer

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Stimulus-specific and differential distribution of activated extracellular signal-regulated kinase in the nucleus accumbens core and shell during Pavlovian-instrumental transfer

Content Provider	Springer Nature Link
Author	Remus, Merissa L. Thiels, Edda
Copyright Year	2012
Abstract	The ability of reward-predictive cues to potentiate reward-seeking behavior—a phenomenon termed Pavlovian-instrumental transfer (PIT)—depends on the activation of extracellular signal-regulated kinase (ERK) in the nucleus accumbens (NAc). Here, we utilized immunohistochemistry to investigate the subregional pattern of ERK activation during PIT, and the contribution of different elements in the PIT condition to the distribution of ERK signaling in the NAc of rats. We found that the occurrence of reward-seeking behavior (lever pressing) did not affect ERK activation in either the core or the shell of the NAc. In contrast, presentation of the reward-predictive cue (auditory conditioned stimulus) caused a significant increase in ERK activation in both subregions of the NAc, with the effect being slightly more robust in the core than the shell. Different from the pattern evoked by the reward-predictive cue, presentation of the reward itself (food pellets) had no effect on ERK activation in the core but caused a pronounced increase in ERK activation in the shell. Taken together, our results demonstrate that ERK signaling in the NAc during PIT involves both the core and the shell and is driven by the conditioned cue irrespective of whether the situation permits engagement in reward-seeking behavior. Furthermore, our results show that the subregional distribution of ERK signaling in the NAc evoked by rewards differs from that evoked by cues that predict them. The stimulus-specific differential pattern of ERK signaling described here may present the molecular complement to stimulus-specific increases in NAc cell firing reported previously.
Starting Page	913
Ending Page	927
Page Count	15
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	218
Issue Number	4
e-ISSN	18632661
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-07-05
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Reward Motivation Conditioned stimulus MAP kinase Immunohistochemistry Neurosciences Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

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