NDLI: Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression

Content Provider	Springer Nature Link
Author	Ginsberg, Stephen D. Che, Shaoli Hashim, Audrey Zavadil, Jiri Cancro, Robert Lee, Sang H. Petkova, Eva Sershen, Henry W. Volavka, Jan
Copyright Year	2011
Abstract	This study was designed to understand molecular and cellular mechanisms underlying aggressive behaviors in mice exposed to repeated interactions in their homecage with conspecifics. A resident–intruder procedure was employed whereby two males were allowed to interact for 10 min trials, and aggressive and/or submissive behaviors (e.g., degree of attacking, biting, chasing, grooming, rearing, or upright posture) were assessed. Following 10 days of behavioral trials, brains were removed and dissected into specific regions including the cerebellum, frontal cortex, hippocampus, midbrain, pons, and striatum. Gene expression analysis was performed using real-time quantitative polymerase-chain reaction (qPCR) for catechol-O-methyltransferase (COMT) and tyrosine hydroxylase (TH). Compared to naive control mice, significant up regulation of COMT expression of residents was observed in the cerebellum, frontal cortex, hippocampus, midbrain, and striatum; in all of these brain regions the COMT expression of residents was also significantly higher than that of intruders. The intruders also had a significant down regulation (compared to naive control mice) within the hippocampus, indicating a selective decrease in COMT expression in the hippocampus of submissive subjects. Immunoblot analysis confirmed COMT up regulation in the midbrain and hippocampus of residents and down regulation in intruders. qPCR analysis of TH expression indicated significant up regulation in the midbrain of residents and concomitant down regulation in intruders. These findings implicate regionally- and behaviorally-specific regulation of COMT and TH expression in aggressive and submissive behaviors. Additional molecular and cellular characterization of COMT, TH, and other potential targets is warranted within this animal model of aggression.
Starting Page	347
Ending Page	356
Page Count	10
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	216
Issue Number	4
e-ISSN	18632661
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-04-22
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hippocampus Midbrain qPCR Resident–intruder Social defeat Tyrosine hydroxylase Cell Biology Neurology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

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