NDLI: Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex

Content Provider	Springer Nature Link
Author	Shapiro, Lee A. Ng, Kwan L. Kinyamu, Richard Whitaker Azmitia, Patricia Geisert, Eldon E. Blurton Jones, Mathew Zhou, Qun Yong Ribak, Charles E.
Copyright Year	2007
Abstract	Newly generated neurons are continuously added to the olfactory epithelium and olfactory bulbs of adult mammals. Studies also report newly generated neurons in the piriform cortex, the primary cortical projection site of the olfactory bulbs. The current study used BrdU-injection paradigms, and in vivo and in vitro DiI tracing methods to address three fundamental issues of these cells: their origin, migratory route and fate. The results show that 1 day after a BrdU-injection, BrdU/DCX double-labeled cells appear deep to the ventricular subependyma, within the white matter. Such cells appear further ventral and caudal in the ensuing days, first appearing in the rostral piriform cortex of mice at 2 days after the BrdU-injection, and at 4 days in the rat. In the caudal piriform cortex, BrdU/DCX labeled cells first appear at 4 days after the injection in mice and 7 days in rats. The time it takes for these cells to appear in the piriform cortex and the temporal distribution pattern suggest that they migrate from outside this region. DiI tracing methods confirmed a migratory route to the piriform cortex from the ventricular subependyma. The presence of BrdU/NeuN labeled cells as early as 7 days after a BrdU injection in mice and 10 days in the rat and lasting as long as 41 days indicates that some of these cells have extended survival durations in the adult piriform cortex.
Starting Page	133
Ending Page	148
Page Count	16
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	212
Issue Number	2
e-ISSN	18632661
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-09-01
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurogenesis Olfactory system Doublecortin Bromodeoxyuridine DiI tracing Neurology Cell Biology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

New neurons from old beliefs in the adult piriform cortex? A Commentary on: “Occurrence of new neurons in the piriform cortex”

Sensitivity to the photoperiod and potential migratory features of neuroblasts in the adult sheep hypothalamus

Comparison of Newly Generated Doublecortin-immunoreactive Neuronal Progenitors in the Main Olfactory Bulb among Variously Aged Gerbils

In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis

Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus

Properties of Doublecortin-(DCX)-Expressing Cells in the Piriform Cortex Compared to the Neurogenic Dentate Gyrus of Adult Mice

Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb

Interneurons, tau and amyloid-β in the piriform cortex in Alzheimer’s disease

Organization and chemical neuroanatomy of the African elephant (Loxodonta africana) hippocampus

Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex

Similar Documents

New neurons from old beliefs in the adult piriform cortex? A Commentary on: “Occurrence of new neurons in the piriform cortex”

Sensitivity to the photoperiod and potential migratory features of neuroblasts in the adult sheep hypothalamus

Comparison of Newly Generated Doublecortin-immunoreactive Neuronal Progenitors in the Main Olfactory Bulb among Variously Aged Gerbils

In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis

Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus

Properties of Doublecortin-(DCX)-Expressing Cells in the Piriform Cortex Compared to the Neurogenic Dentate Gyrus of Adult Mice

Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb

Interneurons, tau and amyloid-β in the piriform cortex in Alzheimer’s disease

Organization and chemical neuroanatomy of the African elephant (Loxodonta africana) hippocampus

Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex