NDLI: Spatial patterns of neuronal activity in rat cerebral cortex during non-rapid eye movement sleep

Content Provider	Springer Nature Link
Author	Wanger, Tim Wetzel, Wolfram Scheich, Henning Ohl, Frank W. Goldschmidt, Jürgen
Copyright Year	2014
Abstract	It is commonly assumed that cortical activity in non-rapid eye movement sleep (NREMS) is spatially homogeneous on the mesoscopic scale. This is partly due to the limited observational scope of common metabolic or imaging methods in sleep. We used the recently developed technique of thallium-autometallography (TlAMG) to visualize mesoscopic patterns of activity in the sleeping cortex with single-cell resolution. We intravenously injected rats with the lipophilic chelate complex thallium diethyldithiocarbamate (TlDDC) during spontaneously occurring periods of NREMS and mapped the patterns of neuronal uptake of the potassium (K+) probe thallium (Tl+). Using this method, we show that cortical activity patterns are not spatially homogeneous during discrete 5-min episodes of NREMS in unrestrained rats—rather, they are complex and spatially diverse. Along with a relative predominance of infragranular layer activation, we find pronounced differences in metabolic activity of neighboring neuronal assemblies, an observation which lends support to the emerging paradigm that sleep is a distributed process with regulation on the local scale.
Starting Page	3469
Ending Page	3484
Page Count	16
File Format	PDF
ISSN	18632653
Journal	Anatomy and Embryology
Volume Number	220
Issue Number	6
e-ISSN	18632661
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-08-13
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cortical columns Infragranular layers Laminar microcircuits Slow-wave sleep Thallium-autometallography Neurosciences Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Anatomy Histology

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