NDLI: A genomewide survey of developmentally relevant genes in Ciona intestinalis : X. Genes for cell junctions and extracellular matrix

Content Provider	Springer Nature Link
Author	Sasakura, Yasuri Shoguchi, Eiichi Takatori, Naohito Wada, Shuichi Meinertzhagen, Ian A. Satou, Yutaka Satoh, ri
Copyright Year	2003
Abstract	Cell junctions and the extracellular matrix (ECM) are crucial components in intercellular communication. These systems are thought to have become highly diversified during the course of vertebrate evolution. In the present study, we have examined whether the ancestral chordate already had such vertebrate systems for intercellular communication, for which we have searched the genome of the ascidian Ciona intestinalis. From this molecular perspective, the Ciona genome contains genes that encode protein components of tight junctions, hemidesmosomes and connexin-based gap junctions, as well as of adherens junctions and focal adhesions, but it does not have those for desmosomes. The latter omission is curious, and the ascidian type-I cadherins may represent an ancestral form of the vertebrate type-I cadherins and desmosomal cadherins, while Ci-Plakin may represent an ancestral protein of the vertebrate desmoplakins and plectins. If this is the case, then ascidians may have retained ancestral desmosome-like structures, as suggested by previous electron-microscopic observations. In addition, ECM genes that have been regarded as vertebrate-specific were also found in the Ciona genome. These results suggest that the last common ancestor shared by ascidians and vertebrates, the ancestor of the entire chordate clade, had essentially the same systems of cell junctions as those in extant vertebrates. However, the number of such genes for each family in the Ciona genome is far smaller than that in vertebrate genomes. In vertebrates these ancestral cell junctions appear to have evolved into more diverse, and possibly more complex, forms, compared with those in their urochordate siblings.
Starting Page	303
Ending Page	313
Page Count	11
File Format	PDF
ISSN	0949944X
Journal	Development Genes and Evolution
Volume Number	213
Issue Number	5-6
e-ISSN	1432041X
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-05-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Basal chordates Ciona intestinalis Genomewide survey Genes Cell junctions Developmental Biology Neurosciences Cell Biology Biochemistry Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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