NDLI: Conservation of male-specific expression of novel phosphoprotein phosphatases in Drosophila

Content Provider	Springer Nature Link
Author	Ádám, Csaba Henn, László Miskei, Márton Erdélyi, Miklós Friedrich, Péter Dombrádi, Viktor
Copyright Year	2010
Abstract	In the genome of Drosophila melanogaster, there are 19 phosphoprotein phosphatase (PPP) catalytic subunit coding genes. Seven of the novel members of the gene family turned out to be Drosophila-specific. The expression and evolution of these genes was investigated in the present study. CG11597 is a recently evolved gene that is expressed during all stages of morphogenesis in D. melanogaster. In contrast, the transcription of PpD5, PpD6, Pp1-Y1, and Pp1-Y2 genes is restricted to the pupa and imago developmental stages and to the testis of the males, just as that of the previously characterized PpY-55A and PpN58A. With the exception of the Y-localized Pp1-Y1 and Pp1-Y2, the testis-specific phosphatase genes are expressed in X/0 males, while none of them are expressed in XX/Y females. The mRNA of PpD5, Pp1-Y1, and PpY-55A were detected in the developing cysts by in situ hybridization, in contrast with the PpD6 transcript that was found in the distal ends of elongating spermatids. The latter localization suggests post-meiotic expression. The comparison of PPP genes in five Drosophila species revealed that the sequence of the six testis-specific phosphatases changed more rapidly than that of the housekeeping phosphatases. Our results support the “faster male” hypothesis. On the other hand, the male-biased expression of the six genes remained conserved during evolution despite the fact that Pp1-Y1, Pp1-Y2, and PpD6 moved from autosomes to the Y chromosome. Interestingly, the PpD6 gene was found to be Y-linked only in Drosophila ananassae.
Starting Page	123
Ending Page	128
Page Count	6
File Format	PDF
ISSN	0949944X
Journal	Development Genes and Evolution
Volume Number	220
Issue Number	3-4
e-ISSN	1432041X
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-07-15
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ser/Thr protein phosphatases Gene expression Testis specificity Drosophila Evolution Animal Genetics and Genomics Neurosciences Biochemistry Cell Biology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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