NDLI: Developmental competence and the induction of ectopic proboscises in Drosophila melanogaster

Content Provider	Springer Nature Link
Author	Percival Smith, Anthony Sivanantharajah, Lovesha Pelling, Jacob J. H. Teft, Wendy A.
Copyright Year	2013
Abstract	Developmental competence is the response of a cell(s) to information. Determination of adult labial identity in Drosophila requires Proboscipedia (PB) and Sex combs reduced (SCR); however, co-ectopic expression of PB and SCR is not sufficient for induction of ectopic adult labial identity, because the developmental information supplied by PB and SCR is suppressed. The evolutionarily conserved LASCY, DYTQL, NANGE motifs, and the C-terminal domain of SCR are sequence elements that mediate some, or all, of the suppression of ectopic proboscis determination. Therefore, the developmentally competent primordial proboscis cells provide an environment devoid of suppression, allowing PB and SCR to determine proboscis identity. SCR derivatives lacking suppression sequences weakly induce ectopic proboscis transformations independently of PB, suggesting that SCR may be the activity required for induction of adult labial identity, as is the case for larval labial identity. A possible explanation for PB independence of SCR in determination of adult and embryonic labial identity is PB operates as a competence factor that switches SCR from determining T1 identity to labial identity during metamorphosis. Lastly, labial determination is not conserved between SCR and murine HOXA5, suggesting that SCR has acquired this activity during evolution.
Starting Page	375
Ending Page	387
Page Count	13
File Format	PDF
ISSN	0949944X
Journal	Development Genes and Evolution
Volume Number	223
Issue Number	6
e-ISSN	1432041X
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-10-12
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hox Sex combs reduced Proboscipedia Conservation of Hox function Segmental identity Developmental competence Hoxa5 Developmental Biology Neurosciences Cell Biology Biochemistry Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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