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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kölsch, Verena Paululat, Achim |
| Copyright Year | 2002 |
| Abstract | . The highly conserved basic helix-loop-helix transcription factor Hand plays a crucial role in cardiogenesis, limb formation and other developmental processes of vertebrates. Humans, mice and other higher vertebrates have two related genes, dHand (also known as Hand2, Hed, Thing2) and eHand (also known as Hand1, Hxt, Thing1), whereas fish and Drosophila have only a single hand gene. We cloned Drosophila hand and studied the embryonic expression in detail by using various tissue-specific markers that allowed us to analyze the identity of hand-expressing cells. We found hand to be expressed in the entire heart, including all cardioblasts and pericardial cells, in the progenitors of the circular visceral muscles, the lymph gland and garland cells, and in a few cells in the CNS. The expression of Drosophila hand starts after the inductive activity of the early regulators in these tissues, e.g. Tinman and Bagpipe, suggesting a role of Hand in differentiation rather than in tissue determination. In many aspects the expression pattern of Drosophila hand resembles the patterns of its vertebrates orthologues, for instance in cardiac tissues. We assume that Hand proteins might play a highly conserved role throughout evolution. Electronic Supplementary Material is available if you access this article at http://dx.doi.org/10.1007/s00427-002-0268-6. On that page (frame on the left side), a link takes you directly to the supplementary material. |
| Starting Page | 473 |
| Ending Page | 485 |
| Page Count | 13 |
| File Format | |
| ISSN | 0949944X |
| Journal | Development Genes and Evolution |
| Volume Number | 212 |
| Issue Number | 10 |
| e-ISSN | 1432041X |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2002-09-21 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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