NDLI: Role of nitric oxide in thermoregulation during septic shock: involvement of vasopressin

Content Provider	Springer Nature Link
Author	Giusti Paiva, Alexandre Branco, Luiz G. S. Castro, Margareth Antunes Rodrigues, José Carnio, Evelin C.
Copyright Year	2003
Abstract	We tested the hypothesis that the nitric oxide (NO) pathway in the central nervous system (CNS) plays a role in hypothermia, as well as in the febrile response during experimental septic shock, by regulating vasopressin (AVP) release. Experiments were performed on male Wistar rats treated with N G-nitro-l-arginine methyl ester (l-NAME), a non-selective NO synthase (NOS) inhibitor, injected intracerebroventricularly (250 µg/1 μl) 30 min before lipopolysaccharide (LPS) 1.5 mg/kg i.v. injection. One hour after LPS administration we observed a significant drop in body temperature (hypothermic response), followed by a temperature increase after the second hour (febrile response), which remained until the end of the experiment. Increased plasmatic AVP levels were concomitantly observed during hypothermia, nearly returning to basal levels during the febrile phase. When l-NAME was administered with LPS, plasmatic AVP concentrations remained high throughout the experiment, hypothermia was accentuated and the febrile response was abolished. Additionally, pre-treatment with β-mercapto-β,β-cyclopentamethylenepropionyl1, O-Et-Tyr2, Val4, Arg8-vasopressin, an AVP V1 receptor blocker (10 µg/kg) administered i.v., reduced hypothermia and exacerbated the febrile response to endotoxin. In conclusion, our data indicate that the central NO pathway plays an inhibitory role in AVP release during experimental septic shock, which seems to be critical for the thermoregulation during this pathophysiological state.
Starting Page	175
Ending Page	180
Page Count	6
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	447
Issue Number	2
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-10-03
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Body temperature Endotoxin LPS Nitric oxide synthase
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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