NDLI: Interactions between the N-terminal tail and the gating machinery of hERG K+ channels both in closed and open/inactive states

Please wait, while we are loading the content...

Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4

Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K+ (Kir2.1) channel

Interactions between the N-terminal tail and the gating machinery of hERG K+ channels both in closed and open/inactive states

Late sodium current (INaL) in pancreatic β-cells

Identification and characterization of the zebrafish ClC-2 chloride channel orthologs

The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor

Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H+ exchanger NHE3 dysfunction in human and murine colitis

Communication between mast cells and rat submucosal neurons

Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion

Low-dose photon irradiation alters cell differentiation via activation of hIK channels

Pflügers Archiv : Volume 467, Issue 7, July 2015

Pflügers Archiv : Volume 467, Issue 6, June 2015

Pflügers Archiv : Volume 467, Issue 5, May 2015

Pflügers Archiv : Volume 467, Issue 4, April 2015

Pflügers Archiv : Volume 467, Issue 3, March 2015

Pflügers Archiv : Volume 467, Issue 2, February 2015

Pflügers Archiv : Volume 467, Issue 1, January 2015

Pflügers Archiv : Volume 466

Pflügers Archiv : Volume 465

Pflügers Archiv : Volume 464

Pflügers Archiv : Volume 463

Pflügers Archiv : Volume 462

Pflügers Archiv : Volume 461

Pflügers Archiv : Volume 460

Pflügers Archiv : Volume 459

Pflügers Archiv : Volume 458

Pflügers Archiv : Volume 457

Pflügers Archiv : Volume 456

Pflügers Archiv : Volume 455

Pflügers Archiv : Volume 454

Pflügers Archiv : Volume 453

Pflügers Archiv : Volume 452

Pflügers Archiv : Volume 451

Pflügers Archiv : Volume 450

Pflügers Archiv : Volume 449

Pflügers Archiv : Volume 448

Pflügers Archiv : Volume 447

Pflügers Archiv : Volume 446

Pflügers Archiv : Volume 445

Pflügers Archiv : Volume 444

Pflügers Archiv : Volume 443

Pflügers Archiv : Volume 442

Pflügers Archiv : Volume 441

Pflügers Archiv : Volume 440

Pflügers Archiv : Volume 439

Pflügers Archiv : Volume 438

Pflügers Archiv : Volume 437

Pflügers Archiv : Volume 436

Pflügers Archiv : Volume 435

Pflügers Archiv : Volume 434

Pflügers Archiv : Volume 433

Interactions between the N-terminal tail and the gating machinery of hERG K+ channels both in closed and open/inactive states

Content Provider	Springer Nature Link
Author	Peña, Pilar Machín, Angeles Fernández Trillo, Jorge Domínguez, Pedro Barros, Francisco
Copyright Year	2014
Abstract	The N-terminal-most N-tail of the human ether-à-go-go-related gene (hERG) potassium channel is a crucial modulator of deactivation through its interactions with the S4-S5 loop and/or the C-linker/cNBD, leading to a stabilization of the channel’s open state. Not only the N-terminal, but also the initial C-terminal region of the channel can modulate the transitions between the open and closed states either by direct or by indirect/allosteric interactions with the gating machinery. However, while a physical proximity of the N-tail to the gating machinery has been demonstrated in the closed state, data about their possible interaction in other channel conformations have been lacking. Using a site-directed cysteine mutagenesis and disulfide chemistry approach, we present here evidence that a physical proximity between the N-tail and the gating-related structures can also exist in channels held between pulses in the open/inactive state, highlighting the physiological and functional relevance of the direct interactions between the N-terminal tail and the S4-S5 loop and/or C-linker structures for modulation of channel.
Starting Page	1747
Ending Page	1756
Page Count	10
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	467
Issue Number	8
e-ISSN	14322013
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-09-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Potassium channel Ether-à-go-go-related gene Disulfide bridging Structure-function relationship Cytoplasmic domains Gating modulation Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Interactions between the N-terminal tail and the gating machinery of hERG Kâº channels both in closed and open/inactive states.

Concerted All-or-none Subunit Interactions Mediate Slow Deactivation of Human ether-à-go-go-related Gene K+ Channels

Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains

Role of ERG1 isoforms in modulation of ERG1 channel trafficking and function

Human Ether-à-go-go–related Gene K+ Channel Gating Probed with Extracellular Ca2+

Gating currents associated with intramembrane charge displacement in HERG potassium channels

Modulation of human ether-à-go-go-related K+ (HERG) channel inactivation by Cs+ and K+

Interactions at Human ether-à-go-go–Related Gene Channels

Molecular Coupling in the Human ether-a-go-go-related gene-1 (hERG1) K+ Channel Inactivation Pathway

Interactions between the N-terminal tail and the gating machinery of hERG K+ channels both in closed and open/inactive states

Similar Documents

Interactions between the N-terminal tail and the gating machinery of hERG Kâº channels both in closed and open/inactive states.

Concerted All-or-none Subunit Interactions Mediate Slow Deactivation of Human ether-à-go-go-related Gene K+ Channels

Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains

Role of ERG1 isoforms in modulation of ERG1 channel trafficking and function

Human Ether-à-go-go–related Gene K+ Channel Gating Probed with Extracellular Ca2+

Gating currents associated with intramembrane charge displacement in HERG potassium channels

Modulation of human ether-à-go-go-related K+ (HERG) channel inactivation by Cs+ and K+

Interactions at Human ether-à-go-go–Related Gene Channels

Molecular Coupling in the Human ether-a-go-go-related gene-1 (hERG1) K+ Channel Inactivation Pathway

Interactions between the N-terminal tail and the gating machinery of hERG K+ channels both in closed and open/inactive states

Interactions between the N-terminal tail and the gating machinery of hERG Kâº channels both in closed and open/inactive states.