NDLI: Regulation of ion channels in rat hepatocytes

Content Provider	Springer Nature Link
Author	Breit, S. Kolb, H. A. Apfel, H. Haberland, C. Schmitt, M. Häussinger, D. Graf, J. Lang, F.
Copyright Year	1998
Abstract	Patch-clamp studies have been performed to elucidate single ion channels in rat hepatocytes. In rat hepatocytes two types of ion channel have been identified: an inwardly rectifying K+ channel with a mean inward conductance of 55 ± 6.5 pS (n = 20) and a mean outward conductance of 25 ± 3.2 pS (n = 20) in the inside-out configuration with 145 mmol/l KCl on either side of the patch as well as an outwardly rectifying Cl– channel with a mean outward conductance of 30 ± 4.5 pS (n = 8) and a mean inward conductance of 10 ± 2.3 pS (n = 6) in the inside-out configuration with symmetrical 145 mmol/l KCl. The open probability of these channels is virtually insensitive to Ca2+ activity on the intracellular side. Accordingly, the Ca2+ ionophore ionomycin had no effect on cell membrane potential. Dibutyryl-cAMP (db-cAMP) hyperpolarizes the cell membrane and increases the activity of the 55-pS inwardly rectifying K+ channel by reducing the duration of closure between bursts. Forskolin similarly hyperpolarizes the cell membrane. The inwardly rectifying K+ channel is inhibited by progesterone, while the outwardly rectifying Cl– channel is insensitive to progesterone.
Starting Page	203
Ending Page	210
Page Count	8
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	435
Issue Number	2
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	1997-12-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Structural analysis of calmodulin binding to ion channels demonstrates the role of its plasticity in regulation

Gating in CNGA1 channels

Regulation of TRP channels by PIP2

Effects of dopamine on ion transport across the rat distal colon

Ion channels in isolated mouse jejunal crypts

Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels

Ion channels in inflammation

Subunits α, β and γ of the epithelial Na+ channel (ENaC) are functionally related to the hypertonicity-induced cation channel (HICC) in rat hepatocytes

Oxygen physiology: sensors and ion channels

Regulation of ion channels in rat hepatocytes

Similar Documents

Structural analysis of calmodulin binding to ion channels demonstrates the role of its plasticity in regulation

Gating in CNGA1 channels

Regulation of TRP channels by PIP2

Effects of dopamine on ion transport across the rat distal colon

Ion channels in isolated mouse jejunal crypts

Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels

Ion channels in inflammation

Subunits α, β and γ of the epithelial Na+ channel (ENaC) are functionally related to the hypertonicity-induced cation channel (HICC) in rat hepatocytes

Oxygen physiology: sensors and ion channels

Regulation of ion channels in rat hepatocytes