NDLI: Calcitonin gene-related peptide suppresses the transient outward current in rat ventricular myocytes

Content Provider	Springer Nature Link
Author	Štengl, Milan Barták, František
Copyright Year	2000
Abstract	The effects of calcitonin gene-related peptide (CGRP) on the transient outward current (I to) and the L-type calcium current (I Ca,L) were investigated in isolated rat ventricular cardiomyocytes using the whole-cell, patch-clamp technique. CGRP influenced neither the amplitude nor the time course of I Ca,L. On the other hand, at all membrane potentials at which a significant I to was elicited, CGRP decreased its amplitude. The effect on I to was completely reversible and independent of membrane potential. The steady-state activation and inactivation curves of I to were not influenced by CGRP. The time course of I to inactivation was satisfactorily fitted by two exponentials. Both the fast and the slow time constants of inactivation were voltage independent and were not influenced by CGRP. The effect of CGRP on I to was concentration dependent with half-maximum inhibition at 99 nM. Chelerythrine, a selective inhibitor of protein kinase C, prevented the effect of CGRP on I to. The data indicate that CGRP suppresses I to in a concentration-dependent, but membrane potential-independent manner and that the effect is probably mediated via a protein kinase C-dependent pathway.
Starting Page	138
Ending Page	143
Page Count	6
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	441
Issue Number	1
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	2000-08-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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