NDLI: Calcium currents in respiratory neurons of the cat in vivo

Content Provider	Springer Nature Link
Author	Pierrefiche, O. Haji, A. Bischoff, A. Richter, D.W.
Abstract	Under in vivo conditions, periodic burst discharges of medullary respiratory neurons of mature cat typically start with a rebound depolarization when inhibition through antagonistic neurons stops. This rebound can be blocked by ionophoretically applied extracellular Cd2+. A similar Cd2+-sensitive rebound depolarization is triggered by hyperpolarizing current pulses even in the presence of extracellular tetrodotoxin (TTX) and tetraethylammonium (TEA). In current-clamp mode, the current/voltage (I/V) curves rectify outwardly at positive voltages, and this rectification is blocked by Cd2+. Intracellular injection of the L-type Ca2+-channel blocker methoxy-verapamil changes the spontaneous activity patterns of neurons. In those neurons that typically show augmenting patterns, the membrane depolarization is slowed down, while in those neurons that have a declining pattern, voltage changes become augmenting. Voltage-clamp measurements reveal a transient, low-voltage-activated T-type Ca2+ current. The current is deinactivated at –100 mV and almost completely inactivated at –60 mV. Depolarizing voltage commands starting from more positive holding potentials evoke sustained Ca2+ currents that reach a maximum at 0 mV. The sustained L-type Ca2+ currents are completely blocked by extracellular Cd2+. We conclude that low- and high-voltage-activated Ca2+ currents are expressed in all types of respiratory neurons and play an essential role in rhythm generation and pattern formation in adult cats in vivo.
Starting Page	817
Ending Page	826
Page Count	10
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	438
Issue Number	6
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-08-31
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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