NDLI: Endurance training increases the efficiency of rat skeletal muscle mitochondria

Content Provider	Springer Nature Link
Author	Zoladz, Jerzy A. Koziel, Agnieszka Woyda Ploszczyca, Andrzej Celichowski, Jan Jarmuszkiewicz, Wieslawa
Copyright Year	2016
Abstract	Endurance training enhances mitochondrial oxidative capacity, but its effect on mitochondria functioning is poorly understood. In the present study, the influence of an 8-week endurance training on the bioenergetic functioning of rat skeletal muscle mitochondria under different assay temperatures (25, 35, and 42 °C) was investigated. The study was performed on 24 adult 4-month-old male Wistar rats, which were randomly assigned to either a treadmill training group (n = 12) or a sedentary control group (n = 12). In skeletal muscles, endurance training stimulated mitochondrial biogenesis and oxidative capacity. In isolated mitochondria, endurance training increased the phosphorylation rate and elevated levels of coenzyme Q. Moreover, a decrease in mitochondrial uncoupling, including uncoupling protein-mediated proton leak, was observed after training, which could explain the increased reactive oxygen species production (in nonphosphorylating mitochondria) and enhanced oxidative phosphorylation efficiency. At all studied temperatures, endurance training significantly augmented H2O2 production (and coenzyme Q reduction level) in nonphosphorylating mitochondria and decreased H2O2 production (and coenzyme Q reduction level) in phosphorylating mitochondria. Endurance training magnified the hyperthermia-induced increase in oxidative capacity and attenuated the hyperthermia-induced decline in oxidative phosphorylation efficiency and reactive oxygen species formation of nonphosphorylating mitochondria via proton leak enhancement. Thus, endurance training induces both quantitative and qualitative changes in muscle mitochondria that are important for cell signaling as well as for maintaining muscle energy homeostasis, especially at high temperatures.
Starting Page	1709
Ending Page	1724
Page Count	16
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	468
Issue Number	10
e-ISSN	14322013
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-08-27
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Endurance training Skeletal muscle mitochondria Temperature Oxidative phosphorylation Uncoupling protein Mitochondria functioning Reactive oxygen species Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Temperature controls oxidative phosphorylation and reactive oxygen species production through uncoupling in rat skeletal muscle mitochondria.

Effect of exercise training on oxidative stress and mitochondrial function in rat heart and gastrocnemius muscle

Oxidative stress and mitochondrial function in skeletal muscle: Effects of aging and exercise training.

Reactive oxygen species activate the group IV muscle afferents in resting and exercising muscle in rats

Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle

Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria

Skeletal muscle reactive oxygen species: a target of good cop/bad cop for exercise and disease.

Effect of exercise training on oxidative stress and mitochondrial function in rat heart and gastrocnemius muscle.

Acyl-coenzyme A binding protein expression is fibre-type specific in rat skeletal muscle but not affected by moderate endurance training

Endurance training increases the efficiency of rat skeletal muscle mitochondria

Similar Documents

Temperature controls oxidative phosphorylation and reactive oxygen species production through uncoupling in rat skeletal muscle mitochondria.

Effect of exercise training on oxidative stress and mitochondrial function in rat heart and gastrocnemius muscle

Oxidative stress and mitochondrial function in skeletal muscle: Effects of aging and exercise training.

Reactive oxygen species activate the group IV muscle afferents in resting and exercising muscle in rats

Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle

Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria

Skeletal muscle reactive oxygen species: a target of good cop/bad cop for exercise and disease.

Effect of exercise training on oxidative stress and mitochondrial function in rat heart and gastrocnemius muscle.

Acyl-coenzyme A binding protein expression is fibre-type specific in rat skeletal muscle but not affected by moderate endurance training

Endurance training increases the efficiency of rat skeletal muscle mitochondria