NDLI: Differential down-regulation of β3-adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats

Content Provider	Springer Nature Link
Author	Scarpace, P. J. Matheny, Michael Tümer, Nihal
Copyright Year	1999
Abstract	Diminished β3 adrenergic-stimulated thermogenesis in brown adipose tissue (BAT) in senescent rats is restored by a short period of cold exposure. To investigate if the mechanism of this restoration involves preferential up-regulation of β3-adrenergic signal transduction in senescent compared with young rats, we examined the steady state levels of β3-adrenergic receptor messenger ribonucleic acid (β3AR mRNA) and the dose/response relationship for the activation of adenylyl cyclase by the selective β3-adrenergic agonist, BRL 37344 in BAT membranes from young and senescent rats with or without 2 days cold exposure at 8 °C. β3AR mRNA declined by 30% with age and by 60% with cold exposure in young rats. In contrast, cold exposure did not down-regulate β3AR mRNA in senescent rats. BRL 37344-stimulated adenylyl cyclase activity was 38% less in senescent rats and was desensitized by cold exposure decreasing maximum stimulation by 78% and increasing, the dissociation constant 2.5-fold. Cold exposure decreased BRL 37344-stimulated adenylyl cyclase activity to a lesser extent in senescent rats (50%), such that the activity was similar in cold-exposed young and old rats. These data indicate that although cold exposure did not, as we hypothesized, up-regulate β3-adrenergic signal transduction in the senescent rats, cold exposure preferentially down-regulated β3AR mRNA and β3AR-mediated adenylyl cyclase in the young compared with senescent rats.
Starting Page	479
Ending Page	483
Page Count	5
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	437
Issue Number	3
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-01-18
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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