NDLI: Connexin 43 is not essential for the control of renin synthesis and secretion

Content Provider	Springer Nature Link
Author	Gerl, Melanie Kurt, Birgül Kurtz, Armin Wagner, Charlotte
Copyright Year	2013
Abstract	The juxtaglomerular areas of mammalian kidneys express the gap junction proteins connexin 37, 40, 43, and 45. Among these, Cx40 plays a major role for the function of juxtaglomerular renin-expressing cells, while Cx37 and Cx45 appear to be less relevant in this context. Since the role of the remaining Cx43 for the function of renin expression is not well understood, this study aimed to systematically characterize the direct role of Cx43 for renin expression and secretion. For this aim, we generated mice with endothelium and with renin cell-specific deletions of Cx43, and we characterized the regulation of renin expression and renin secretion in the kidneys of these mice on normal salt diet and during chronic challenge of the renin system by pretreatment of mice with a low-salt diet in combination with an angiotensin I-converting enzyme inhibitor. We found that renal renin mRNA abundance, plasma renin concentration, and systolic blood pressure did not differ between wild-type, Cx43fl/fl Ren1d+/Cre mice as well as Cx43fl/fl Tie-2+/Cre mice under basal conditions nor under chronic stimulation by salt depletion. The localization of renin-expressing cells was also regular in kidneys of all genotypes, and moreover, regulation of renin secretion by beta-adrenergic stimulation and renal perfusion pressure measured in isolated perfused kidneys of Cx43fl/fl Ren1d+/Cre and Cx43fl/fl Tie-2+/Cre mice was not different from control. We infer from these results that Cx43 plays if at all only a minor role for the functional control of renin-producing cells in the kidney.
Starting Page	1003
Ending Page	1009
Page Count	7
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	466
Issue Number	5
e-ISSN	14322013
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-09-24
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Conditional knockout Blood pressure Plasma renin concentration Endothelium Baroreceptor function Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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Connexin 43 is not essential for the control of renin synthesis and secretion.

Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion

KATP channels are not essential for pressure-dependent control of renin secretion

Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion.

Running head: renin in enos knockouts.

Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney

Distribution and functional relevance of connexins in renin-producing cells

Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney.

Metabolic control of renin secretion

Connexin 43 is not essential for the control of renin synthesis and secretion

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Connexin 43 is not essential for the control of renin synthesis and secretion.

Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion

KATP channels are not essential for pressure-dependent control of renin secretion

Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion.

Running head: renin in enos knockouts.

Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney

Distribution and functional relevance of connexins in renin-producing cells

Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney.

Metabolic control of renin secretion

Connexin 43 is not essential for the control of renin synthesis and secretion