NDLI: “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels

Content Provider	Springer Nature Link
Author	Nairz, Manfred Theurl, Igor Swirski, Filip K. Weiss, Guenter
Copyright Year	2017
Abstract	Macrophages reside in virtually every organ. First arising during embryogenesis, macrophages replenish themselves in the adult through a combination of self-renewal and influx of bone marrow-derived monocytes. As large phagocytic cells, macrophages participate in innate immunity while contributing to tissue-specific homeostatic functions. Among the key metabolic tasks are senescent red blood cell recycling, free heme detoxification, and provision of iron for de novo hemoglobin synthesis. While this systemic mechanism involves the shuttling of iron between spleen, liver, and bone marrow through the concerted function of defined macrophage populations, similar circuits appear to exist within the microenvironment of other organs. The high turnover of iron is the prerequisite for continuous erythropoiesis and tissue integrity but challenges macrophages’ ability to maintain cellular iron homeostasis and immune function.This review provides a brief overview of systemic, microenvironmental, and cellular aspects of macrophage iron handling with a focus on exciting and unresolved questions in the field.
Starting Page	397
Ending Page	418
Page Count	22
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	469
Issue Number	3-4
e-ISSN	14322013
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2017-03-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Macrophage Iron Infection Inflammation Erythrophagocytosis Human Physiology Molecular Medicine Neurosciences Cell Biology Receptors
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels