NDLI: Hemodynamic changes in pseudopregnancy in chronically instrumented, conscious rats are preserved after hysterectomy

Content Provider	Springer Nature Link
Author	Eijndhoven, Hugo W. Slangen, Brigitte F. Heijden, Olivier W. Aardenburg, Robert Spaanderman, Marc E. Peeters, Louis L.
Copyright Year	2001
Abstract	Hemodynamic changes in early-pregnant and pseudopregnant rats are comparable, indicating that the trophoblast does not contribute to these changes. It is unclear whether the presence of the uterus is needed for the normal early-pregnancy hemodynamic adaptation. In this study we tested the hypothesis that uterine factors do not contribute to the systemic hemodynamic changes in early pseudopregnancy. To this end, we studied systemic hemodynamics in conscious pseudopregnant rats subjected to a hysterectomy, and compared these results with those obtained in a control group of pseudopregnant rats. The animals were studied on days 4, 8, 12 and 19 postmating. On day 8 of pseudopregnancy, cardiac output has increased by 23±7% in the hysterectomized group and 15±5% in the control group. In both groups this rise in cardiac output was entirely accomplished by a rise in stroke volume, by 28±8% and 19±5%, respectively. Mean arterial pressure did not change appreciably. Therefore, total peripheral resistance also decreased in both groups (17±6%) by day 8. After day 12 the hemodynamic parameters returned to baseline. We conclude that systemic hemodynamic changes in hysterectomized pseudopregnant rats closely resemble those in intact pseudopregnant rats. Therefore, the uterus does not seem to play a role in these changes. This supports the hypothesis that only hormones from ovarian origin trigger the initial hemodynamic adaptation to early pregnancy.
Starting Page	427
Ending Page	431
Page Count	5
File Format	PDF
ISSN	00316768
Journal	Pflügers Archiv
Volume Number	443
Issue Number	3
e-ISSN	14322013
Language	English
Publisher	Springer-Verlag
Publisher Date	2014-03-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

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