NDLI: Exercise type and volume alter signaling pathways regulating skeletal muscle glucose uptake and protein synthesis

Content Provider	Springer Nature Link
Author	Ahtiainen, Juha P. Walker, Simon Silveninen, Mika Kyröläinen, Heikki Nindl, Bradley C. Häkkinen, Keijo Nyman, Kai Selänne, Harri Hulmi, Juha J.
Copyright Year	2015
Abstract	The aim of this study was to compare activation of cellular signaling pathways regulating protein synthesis and glucose uptake in skeletal muscle between resistance and endurance exercise. Moreover, the effect of resistance exercise volume was examined.Three groups of male volunteers (26 ± 3 years) were examined: 5 × 10 repetition maximum (RM) resistance exercise (RE) with leg press device (5 × 10 RE; n = 8), 10 × 10 RE (n = 11), and endurance exercise (strenuous 50-min walking with extra load on a treadmill; EE; n = 8). Muscle biopsies were obtained from m.vastus lateralis 30 min pre- and post-exercise.Downstream markers of mTORC1, p-p70S6KThr421/Ser424 and p-rpS6Ser240/244, increased more after 10 × 10 RE than after 5 × 10 RE (p < 0.05) and EE (p < 0.01–0.001). Exercise-induced changes in p-IRS-ISer636/639 that inhibit IRS-I signaling via negative feedback from hyperactivated mTORC1 signaling were greater (p < 0.05) after 10 × 10 RE compared with 5 × 10 RE and EE. The changes in energy sensor p-AMPKαThr172 were greater after 10 × 10 RE and EE (p < 0.05–0.01) than after 5 × 10 RE. A major regulator of glucose uptake in muscle, p-AS160Thr642, increased more after 10 × 10 RE than after 5 × 10 RE (p < 0.01) and EE (p < 0.05).10 × 10 RE induced greater activation of important signaling proteins regulating glucose uptake (p-AS160) and protein synthesis (p-p70S6K, p-rpS6) than 5 × 10 RE and EE. The present findings further suggest that, especially after 10 × 10 RE, IRS-I signaling is downregulated and that AS160 is activated through AMPK signaling pathway.
Starting Page	1835
Ending Page	1845
Page Count	11
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	115
Issue Number	9
e-ISSN	14396327
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-04-10
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	mTOR AMPK MAPK GLUT4 translocation Human Physiology Occupational Medicine/Industrial Medicine Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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