NDLI: Basal expression of leukocyte iNOS-mRNA is attenuated in moderately endurance-trained subjects

Content Provider	Springer Nature Link
Author	Niess, A. Fehrenbach, E. Schlotz, E. rthoff, H. Dickhuth, H. H.
Copyright Year	2002
Abstract	Nitric oxide (NO) is generated in immunocompetent cells by inducible NO-synthase (iNOS), and plays an important role in host defense. However, when produced in large amounts, NO can also exert damaging effects, a scenario that is observed during several inflammatory processes. In the study presented here, we investigated the impact of moderate endurance training (running volume: mean 53.1 km·week–1, 95% confidence interval 41.2–65.1 km week–1) on the leukocyte expression of iNOS mRNA. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was used to examine iNOS mRNA expression in total leukocyte samples from 12 male trained subjects (TR) and a control group of 12 untrained men (UT) at rest. Relative iNOS mRNA levels (iNOS/β-actin) were higher in UT (0.88, 0.73–1.03) when compared with TR (0.34, 0.09–0.58, P<0.001). iNOS mRNA was not detectable in 5 of the 12 TR subjects. These initial results show that the basal expression of iNOS mRNA is downregulated by moderate endurance training. Further research should clarify whether regular training also affects the responsiveness of leukocyte iNOS gene expression to stimulatory signals. It would be of interest to establish whether moderate training can exert a suppressive and therefore therapeutic effect on the elevated levels of expression of iNOS observed in, for example, several inflammatory disorders.
Starting Page	93
Ending Page	95
Page Count	3
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	87
Issue Number	1
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2002-03-27
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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