NDLI: Eccentric exercise 48 h prior to simulated diving has no effect on vascular bubble formation in rats

Content Provider	Springer Nature Link
Author	Jørgensen, Arve Ekdahl, Anna Havnes, Marianne B. Eftedal, Ingrid
Copyright Year	2014
Abstract	Decompression sickness (DCS) caused by vascular bubble formation is a major risk when diving. Prior studies have shown that physical exercise has a significant impact in both reducing and increasing bubble formation. There is limited knowledge about the mechanisms, but there are indications that exercise-induced muscle injury prior to diving may cause increased bubble formation. The purpose of this study was to investigate the role of exercise-induced muscle injury as a possible mechanism of bubble formation during diving.Muscle injury was induced by exposing female Sprague–Dawley rats (n = 30) to a single bout of eccentric exercise, 100 min intermittent, downhill (–16°) treadmill running. Forty-eight hours later, the animals were exposed to a 50-min simulated saturation dive (709 kPa) in a pressure chamber, when the degree of muscle injury and inflammation would be the most pronounced. Bubble formation after the dive was observed by ultrasonic imaging for 4 h.No difference in bubble loads was found between the groups at any time despite evident muscle injury. Maximum bubble loads (bubbles cm−2 heart cycle−1) were not different, exercise: 1.6 ± 3.5 SD vs control: 2.2 ± 4.1 SD, P = 0.90, n = 15 in each group.Eccentric exercise performed 48 h prior to diving causes skeletal muscle injury but does not increase the amount of vascular bubbles in rats. The prevailing recommendation is that physical activity prior to diving is a risk factor of DCS. However, present and previous studies implicate that pre-dive physical activity does not increase the DCS risk.
Starting Page	597
Ending Page	605
Page Count	9
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	115
Issue Number	3
e-ISSN	14396327
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-11-14
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bubble formation Decompression sickness Diving Eccentric exercise Inflammation Human Physiology Occupational Medicine/Industrial Medicine Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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