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| Content Provider | Springer Nature Link |
|---|---|
| Author | James, L. Onambele, G. Woledge, R. Skelton, D. Woods, D. Eleftheriou, K. Hawe, E. Humphries, S. E. Haddad, F. Montgomery, H. |
| Copyright Year | 2004 |
| Abstract | A reduction in interleukin-6 (IL-6) activity may contribute to the beneficial effects of hormone replacement therapy (HRT) on the menopausal decline in bone mineral density (BMD). We have examined this hypothesis using a genetic strategy. The –174C (rather than G) IL-6 gene variant is associated with lower IL-6 expression. As such, we might anticipate the C allele to be associated with a greater response to HRT. We have tested this hypothesis. Mean three-site [spine (L1-L4), neck of femur, and Ward’s triangle] BMD was measured in 65 women in a 1-year randomised controlled trial of HRT with 0.625 mg oestrogen/day and 0.15 mg norgestrel (n=30). Baseline BMD was genotype-independent for both the control and HRT group. In the control group, the percentage change in BMD after 1 year was similar between genotypes (P=0.45). In contrast, in the HRT group, the rise was genotype-dependent. Those homozygous for the G allele showed a 3.62 (2.14)% increase in BMD compared with 10.44 (4.68)% for the C-homozygous group. Heterozygotes had an intermediate BMD increase of 5.6 (2.82)% [P=0.006 (P value for interaction between HRT and genotype was 0.04)] Although the study was limited by its small sample size, these are the first data to demonstrate the importance of IL-6 genotype in determining response to oestrogen therapy, rather than its physiological withdrawal. |
| Starting Page | 227 |
| Ending Page | 230 |
| Page Count | 4 |
| File Format | |
| ISSN | 14396319 |
| Journal | European Journal of Applied Physiology |
| Volume Number | 92 |
| Issue Number | 1 |
| e-ISSN | 14396327 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2004-04-09 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Interleukin-6 Polymorphism Bone remodelling Hormone replacement therapy Bone mineral density |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science |
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