NDLI: Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women

Content Provider	Springer Nature Link
Author	Ellefsen, S. Vikmoen, O. Slettaløkken, G. Whist, J. E. Nygaard, H. Hollan, I. Rauk, I. Vegge, G. Strand, T. A. Raastad, T. Rønnestad, B. R.
Copyright Year	2014
Abstract	To investigate the effects of strength training on abundances of irisin-related biomarkers in skeletal muscle and blood of untrained young women, and their associations with body mass composition, muscle phenotype and levels of thyroid hormones.Eighteen untrained women performed 12 weeks of progressive whole-body heavy strength training, with measurement of strength, body composition, expression of irisin-related genes (FNDC5 and PGC1α) in two different skeletal muscles, and levels of serum-irisin and -thyroid hormones, before and after the training intervention.The strength training intervention did not result in changes in serum-irisin or muscle FNDC5 expression, despite considerable effects on strength, lean body mass (LBM) and skeletal muscle phenotype. Our data indicate that training affects irisin biology in a LBM-dependent manner. However, no association was found between steady-state serum-irisin or training-associated changes in serum-irisin and alterations in body composition. FNDC5 expression was higher in m.Biceps brachii than in m.Vastus lateralis, with individual expression levels being closely correlated, suggesting a systemic mode of transcriptional regulation. In pre-biopsies, FNDC5 expression was correlated with proportions of aerobic muscle fibers, a relationship that disappeared in post-biopsies. No association was found between serum-thyroid hormones and FNDC5 expression or serum-irisin.No evidence was found for an effect of strength training on irisin biology in untrained women, though indications were found for a complex interrelationship between irisin, body mass composition and muscle phenotype. FNDC5 expression was closely associated with muscle fiber composition in untrained muscle.
Starting Page	1875
Ending Page	1888
Page Count	14
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	114
Issue Number	9
e-ISSN	14396327
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-06-07
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Irisin FNDC5 Lean body mass Fat mass Muscle fiber Skeletal muscle Strength training Thyroid hormones Exercise Myosin heavy chain MHC MyHC mRNA Real-time RT-PCR qRT-PCR Metabolism Human Physiology Occupational Medicine/Industrial Medicine Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women