NDLI: The effect of acute exercise on endothelial progenitor cells is attenuated in chronic heart failure

Content Provider	Springer Nature Link
Author	Craenenbroeck, Emeline M. Bruyndonckx, Luc Berckelaer, Christophe Hoymans, Vicky Y. Vrints, Christiaan J. Conraads, Viviane M.
Copyright Year	2011
Abstract	Exercise training improves endothelial function in patients with chronic heart failure (CHF) through functional enhancement of circulating angiogenic cells and increased numbers of circulating endothelial progenitor cells (EPC). In contrast to healthy subjects, an immediate effect of acute exercise on CD34+/KDR+ EPC is absent in CHF. Whether this reflects an attenuated or rather delayed mobilization, is addressed in the present study by measuring CD34+/KDR+ EPC over a longer time period post-exercise. Seven CHF patients and eight healthy subjects (HS; 4 young and 4 age-matched subjects) underwent graded exercise testing (GXT). Venous blood was sampled before and 10, 30, and 60 min, 2, 4, 8, 12, 24 and 48 h following GXT to determine numbers of circulating CD34+/KDR+ EPC (flow cytometry) and serum levels of stromal cell-derived factor (SDF)-1α (ELISA). In both HS groups, CD34+/KDR+ EPC numbers increased within 10 min following GXT and remained elevated for up to 2 h. In CHF patients, the initial increase was small and normalized within 30 min. Evolution of CD34+/KDR+ EPC numbers over time following GXT overall was attenuated in CHF versus HS (p = 0.036). Exercise considerably influenced SDF-1α levels over time (p = 0.0008), without a relation to the changes in CD34+/KDR+ EPC. The immediate effect of acute exercise on CD34+/KDR+ EPC numbers is not delayed, but significantly attenuated in CHF patients compared to HS.
Starting Page	2375
Ending Page	2379
Page Count	5
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	111
Issue Number	9
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-02-03
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Acute exercise Chronic heart failure CD34+/KDR+ progenitor cells SDF-1α Human Physiology Occupational Medicine/Industrial Medicine Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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