NDLI: Arterioles’ contribution to oxygen supply to the skeletal muscles at rest

Content Provider	Springer Nature Link
Author	Shibata, Masahiro Ichioka, Shigeru Togawa, Tatsuo Kamiya, Akira
Copyright Year	2006
Abstract	We tested the hypothesis that oxygen is supplied to the resting skeletal muscle by arterioles rather than by capillaries. This hypothesis was evaluated in rats and rabbits by combining different approaches (1) determination of the intravascular oxygen tension (PO2) in arterioles of different diameters, (2) measurement of the perfused capillary number in response to changes in tissue PO2, and (3) estimation of the optimum capillary number to provide oxygen efficiently to the surrounding tissue. The intravascular PO2 values of arterioles along the vessels decreased downstream, suggesting that a significant amount of oxygen diffuses from the arterioles to the surrounding tissue. The perfused capillary number decreased as the tissue PO2 level was elevated, and this mutual relationship displayed a nonlinear correlation. The results suggest that a boundary PO2 level affecting the capillary recruitment exists for tissue PO2 of less than 40 mmHg with the capillary blood-flow stops above that PO2 level. At a high PO2 level, therefore, the oxygen is supplied from the arterioles. Furthermore, an estimation of optimum capillary number reveals that the capillary arrangement is constructed to achieve sufficient oxygen supply to the muscle during exercise, rather than at rest. These results suggest that oxygen is supplied from arterioles to the resting skeletal muscle, whereas the oxygen is supplied from the capillaries during exercise.
Starting Page	327
Ending Page	331
Page Count	5
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	97
Issue Number	3
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-04-25
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Krogh model Oxygen transport Arterioles Vascular walls Skeletal muscle
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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