NDLI: Pure eccentric exercise does not activate blood coagulation

Content Provider	Springer Nature Link
Author	Hilberg, Thomas Gläser, Doreen Prasa, Dagmar Stürzebecher, Jörg Gabriel, Holger H. W.
Copyright Year	2005
Abstract	Eccentric exercise can cause skeletal muscle damage with ultrastructural disruption, inflammation and increased proteolytic enzyme activity. It may be possible that these changes are able to trigger blood coagulation in vivo. The aim of the study was to investigate changes in blood coagulation via the measurement of aPTT, the thrombin potential (total [TTP] and endogenous [ETP], both intrinsic [in] and extrinsic [ex]) and the thrombin generation (prothrombinfragment 1+2 [F1+2] and thrombin-antithrombin complex [TAT]) after pure eccentric exercise. Seventeen healthy non-smokers (28±6 years, VO2-peak 59±7 ml/min/kg) underwent pure eccentric down jumps (9×28 isolated down jumps in 90 min, drop from a height of 55 cm), a cycle exercise (90% of the individual anaerobic threshold for 60–90 min) and a control experiment on different days. Blood samples were drawn after a 30-min rest, immediately, and 2 h after exercise. After the cycle exercise, a clear shortening by 12% (P<0.001) in aPTT and an increase in TTPin (13%; P<0.05) and TAT (33%; P<0.05) in comparison to the control experiment were seen, while after eccentric exercise only minimal changes in aPTT and thrombin potential (TTPin, ETPin) and no thrombin generation (F1+2 and TAT) were found. In contrast to concentric dynamic exercise, e.g. cycle ergometry, only insignificant changes in thrombin potential and no thrombin generation could be observed after skeletal muscle damage induced by pure eccentric exercise. It can be concluded that the mechanical impact associated with eccentric exercise does not activate blood coagulation.
Starting Page	718
Ending Page	721
Page Count	4
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	94
Issue Number	5
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-05-20
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TAT F1+2 Thrombin potential ETP Eccentric
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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