NDLI: Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy

Content Provider	Springer Nature Link
Author	Bravo, Daniela M. Gimenes, Ana Cristina Nascimento, Rúbia B. Ferreira, Eloara V. M. Siqueira, Ana Cristina B. Meda, Ethiane D. S. Neder, J. Alberto Nery, Luiz Eduardo
Copyright Year	2011
Abstract	This study addressed whether O2 delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to O2 utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary O2 uptake $$ (\dot{V}{\text{O}}_{2} {\text{p}}), $$ (2) an index of fractional O2 extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (Q T ′ ) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of $$ \dot{V}{\text{O}}_{2} {\text{p}} $$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). Q T ′ , however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than $$ \dot{V}{\text{O}}_{2} {\text{p}} $$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, $$ \tau \dot{V}{\text{O}}_{2} {\text{p}} $$ in patients and controls, respectively. In fact, there were no between-group differences in $$ \tau \dot{V}{\text{O}}_{2} {\text{p}} $$ /MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular O2 delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular O2 delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population.
Starting Page	1763
Ending Page	1771
Page Count	9
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	112
Issue Number	5
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-09-04
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mitochondrial myopathy Reoxygenation Oxygen uptake Kinetics Exercise recovery Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The effect of prior exercise intensity on oxygen uptake kinetics during high-intensity running exercise in trained subjects

Supplemental oxygen and muscle metabolism in mitochondrial myopathy patients

Oxygen uptake kinetics during treadmill running across exercise intensity domains

Oxygen uptake kinetics during exercise in adults with Down syndrome

Indices of electromyographic activity and the “slow” component of oxygen uptake kinetics during high-intensity knee-extension exercise in humans

Oxygen uptake, cardiac output and muscle deoxygenation at the onset of moderate and supramaximal exercise in humans

Isometric strength training lowers the O2 cost of cycling during moderate-intensity exercise

Effects of glutamine and hyperoxia on pulmonary oxygen uptake and muscle deoxygenation kinetics

Resting mechanomyography before and after resistance exercise

Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy

Similar Documents

The effect of prior exercise intensity on oxygen uptake kinetics during high-intensity running exercise in trained subjects

Supplemental oxygen and muscle metabolism in mitochondrial myopathy patients

Oxygen uptake kinetics during treadmill running across exercise intensity domains

Oxygen uptake kinetics during exercise in adults with Down syndrome

Indices of electromyographic activity and the “slow” component of oxygen uptake kinetics during high-intensity knee-extension exercise in humans

Oxygen uptake, cardiac output and muscle deoxygenation at the onset of moderate and supramaximal exercise in humans

Isometric strength training lowers the O2 cost of cycling during moderate-intensity exercise

Effects of glutamine and hyperoxia on pulmonary oxygen uptake and muscle deoxygenation kinetics

Resting mechanomyography before and after resistance exercise

Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy