NDLI: A simple method to clamp end-tidal carbon dioxide during rest and exercise

Content Provider	Springer Nature Link
Author	Olin, J. Tod Dimmen, Andrew C. Subudhi, Andrew W. Roach, Robert C.
Copyright Year	2012
Abstract	Carbon dioxide regulates ventilation and cerebral blood flow during exercise. There are significant limitations in breathing systems designed to control end-tidal gas concentrations when used during high-intensity exercise. We designed a simple, inexpensive breathing system which controls end-tidal carbon dioxide ( $$ {\text{PET}}_{{{\text{CO}}_{2} }} $$ ) during exercise from rest to peak work capacity (W max). The system is operated by an investigator who, in response to breath-by-breath $$ {\text{PET}}_{{{\text{CO}}_{2} }} $$ , titrates flow of a 10 % CO2, 21 % O2 mixture into an open-ended 5-L inspiratory reservoir. To demonstrate system efficacy, nine fit male subjects performed two maximal, incremental exercise tests (25 W min−1 ramp) on a cycle ergometer: a poikilocapnic control trial in which $$ {\text{PET}}_{{{\text{CO}}_{2} }} $$ varied with work intensity, and an experimental trial, in which we planned to clamp $$ {\text{PET}}_{{{\text{CO}}_{2} }} $$ at 50 mmHg. With our breathing system, we maintained $$ {\text{PET}}_{{{\text{CO}}_{2} }} $$ at 51 ± 2 mmHg throughout exercise (rest, 50 ± 2; W max, 52 ± 5 mmHg; mean ± SD) despite large changes in ventilation (range 27–65 at rest, 134–185 L min−1 BTPS at W max) and carbon dioxide production (range 0.3–0.7 at rest, 4.5–5.5 L min−1 at W max). This simple, inexpensive system achieves $$ {\text{PET}}_{{{\text{CO}}_{2} }} $$ control at rest and throughout exercise.
Starting Page	3439
Ending Page	3444
Page Count	6
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	112
Issue Number	9
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-06-27
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Carbon dioxide clamp Maximal exercise Exercise limitation Ventilatory control Human Physiology Sports Medicine Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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