NDLI: The effect of physical conditioning on antipyrine clearance

Content Provider	Springer Nature Link
Author	Villa, J. G. Cuadrado, G. Bayón, J. E. González Gallego, J.
Copyright Year	1998
Abstract	The effects of physical conditioning on antipyrine clearance were studied in two groups of subjects. Healthy men not engaged in the systematic practice of any sport were compared with endurance runners (defined as men running >80 km/week). Studies were carried out at three different periods of the annual plan training at 4-month intervals. Antipyrine was administered orally and pharmacokinetic parameters were obtained from saliva samples by the multiple-sample method. Endurance performance, expressed in terms of the maximal oxygen uptake (V˙O2 max), the ventilatory threshold and the 4-mM · l−1 lactate threshold (OBLA), was higher in trained than in control subjects at each of the three periods. Antipyrine clearance was also significantly elevated and antipyrine half-life reduced in runners during all periods. No significant difference in V˙O2 max or antipyrine clearance was found between the various periods in either trained or control subjects. Both ventilatory threshold and OBLA increased significantly along the training period in conditioned subjects. Significant correlations were found between antipyrine clearance and V˙O2 max, ventilatory threshold and OBLA. In summary, these results indicate an association between aerobic conditioning and increased hepatic oxidative metabolism of low-clearance drugs.
Starting Page	106
Ending Page	111
Page Count	6
File Format	PDF
ISSN	03015548
Journal	European Journal of Applied Physiology
Volume Number	77
Issue Number	1
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	1997-12-08
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Public Health, Environmental and Occupational Health

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